Evidence map›Paper›PMID 28096089›Full record

ArticleBlood2017

Tolerogenic interactions between CD8

David Hongo, Xiaobin Tang, Xiangyue Zhang, Edgar G Engleman, Samuel Strober

Open access · bronzeAbstract read
In one paragraph

Article in Blood, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Combined nonmyeloablative total lymphoid irradiation and low-dose total body irradiation enhances donor chimerism and leads to islet allograft acceptance.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026
    Article
  3. Review
  4. Review
  5. Article
  6. Immune regulation through tryptophan metabolism.Experimental & molecular medicine · 2023
    Review
  7. Review
  8. Review
  9. Unconventional T cells and kidney disease.Nature reviews. Nephrology · 2021
    Review
  10. Article
  11. Article
  12. Review
  13. Natural and Induced Tolerogenic Dendritic Cells.Journal of immunology (Baltimore, Md. : 1950) · 2020
    Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

David HongoDivision of Immunology and Rheumatology, Department of Medicine, and.
Xiaobin TangDivision of Immunology and Rheumatology, Department of Medicine, and.
Xiangyue ZhangDepartment of Pathology, Stanford University School of Medicine, Stanford, CA.
Edgar G EnglemanDivision of Immunology and Rheumatology, Department of Medicine, and.
Samuel StroberDivision of Immunology and Rheumatology, Department of Medicine, and.
Center for Rheumatology · USStanford University · US

Funding

TLI/ATG CONDTIONING: KIDNEY/BLOOD STEM CELL TRANSPLANTSP01HL075462 · NHLBI · STANFORD UNIVERSITY · PI ENGLEMAN, EDGAR G. · 2004 to 2020
$27.9M
DONOR CELL FACILITATION OF TOLERANCER01AI037683 · NIAID · STANFORD UNIVERSITY · PI STROBER, SAMUEL · 1995 to 2011
$3.2M
Role of Dendritic Cells in Mixed Chimerism and ToleranceR01AI118884 · NIAID · STANFORD UNIVERSITY · PI ENGLEMAN, EDGAR G., STROBER, SAMUEL · 2015 to 2019
$1.8M
NHLBI NIH HHS P01 HL075462NIAID NIH HHS R01 AI037683NIAID NIH HHS R01 AI118884
6 · The paper itself

Abstract

The combination of total lymphoid irradiation and anti-T-cell antibodies safely induces immune tolerance to combined hematopoietic cell and organ allografts in humans. Our mouse model required host natural killer T (NKT) cells to induce tolerance. Because NKT cells normally depend on signals from CD8

Indexed as

Immune ToleranceAnimalsBone Marrow TransplantationCD8-Positive T-LymphocytesCell CommunicationDendritic CellsGraft RejectionHeart TransplantationMiceNatural Killer T-Cells

Identifiers

PMID28096089
PMCPMC5364338
OpenAlexW2579019451

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.