Evidence map›Paper›PMID 28096047›Full record

ArticleInternational journal of cardiology2017

Cellular basis of angiotensin-(1-7)-induced augmentation of left ventricular functional performance in heart failure.

Xiaowei Zhang, Heng-Jie Cheng, Peng Zhou, Dalane W Kitzman, Carlos M Ferrario, Wei-Min Li, Che Ping Cheng

Abstract read
In one paragraph

Article in International journal of cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 27 citations in OpenAlex.

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  3. Chronic CaThe Journal of pharmacology and experimental therapeutics · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Xiaowei ZhangDepartment of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Heng-Jie ChengSection on Cardiovascular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, United States.
Peng ZhouSection on Cardiovascular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, United States.
Dalane W KitzmanSection on Cardiovascular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, United States.
Carlos M FerrarioDepartment of Surgery, Wake Forest School of Medicine, Winston-Salem, NC, United States; Department of Internal Medicine-Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, United States; Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
Wei-Min LiDepartment of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address: liweimin_2009@163.com.
Che Ping ChengDepartment of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China; Section on Cardiovascular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, United States. Electronic address: ccheng@wakehealth.edu.
Wake Forest University · USFirst Affiliated Hospital of Harbin Medical University · CNHarbin Medical University · CN

Funding

Vaso-Hormonal Mechanisms in HypertensionP01HL051952 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DELL'ITALIA, LOUIS J. · 1994 to 2019
$34.8M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
New Molecular Target for Cardiac AgingR01AG049770 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CHENG, HENG-JIE · 2015 to 2019
$1.6M
Beta3-Adrenergic Receptor &Progression to Heart FailureR01HL074318 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CHENG, CHE-PING · 2003 to 2006
$1.3M
NCATS NIH HHS UL1 TR001420NHLBI NIH HHS P01 HL051952NHLBI NIH HHS R01 HL074318NIA NIH HHS R01 AG049770
6 · The paper itself

Abstract

backgroundAngiotensin-(1-7) [Ang-(1-7)] exhibits cardiovascular effects opposite those of angiotensin II (Ang II), thus providing protection against heart disease. However, how Ang-(1-7) imparts cardioprotection is unclear, and its direct cardiac effects are controversial. Whether heart failure (HF) alters cardiac contractile responses to Ang-(1-7) remains undetermined. We tested the hypothesis that in HF, Ang-(1-7) may produce positive modulation on [Ca METHODS AND

resultsWe measured LV contractility changes after Ang-(1-7) (650ng/kg, iv) and compared myocyte functional and [Ca

conclusionsIn a rat model of HF, Ang-(1-7) increases [Ca

Indexed as

Angiotensin IAnimalsHeart FailureMaleMyocytes, CardiacPeptide FragmentsRatsVasodilator AgentsVentricular Function, LeftAngiotensin Iangiotensin I (1-7)Peptide FragmentsVasodilator AgentsAngiotensin-(1-7)Calcium transientCellsContractilityHeart failurePressure-volume relation

Identifiers

PMID28096047
PMCPMC5798248
OpenAlexW2567722614

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.