ArticleMicrobiome2017
Ancient bacteria of the Ötzi's microbiome: a genomic tale from the Copper Age.
Article in Microbiome, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 69 citations in OpenAlex.
- Ötzi the Iceman: forensic 3D reconstructions of a 5300-year-ago murder case.International journal of legal medicine · 2025Article
- Characterizing the resistome ofFrontiers in microbiology · 2025Article
- Unraveling the ancient fungal DNA from the Iceman gut.BMC genomics · 2024Article
- Sequencing-based analysis of microbiomes.Nature reviews. Genetics · 2024Review
- Filtering out the noise: metagenomic classifiers optimize ancient DNA mapping.Briefings in bioinformatics · 2024Article
- Antibiotic resistance gene dynamics in the commensal infant gut microbiome over the first year of life.Scientific reports · 2024Article
- A Probiotic Amylase Blend Positively Impacts Gut Microbiota Modulation in a Randomized, Placebo-Controlled, Double-Blind Study.Life (Basel, Switzerland) · 2024Article
- Genetic diversity and phylogenetic relationships of Clostridium perfringens strains isolated from mastitis and enteritis in Egyptian dairy farms.BMC microbiology · 2024Article
- Inferring diet, disease and antibiotic resistance from ancient human oral microbiomes.Microbial genomics · 2024Review
- Multi-omics for studying and understanding polar life.Nature communications · 2023Review
- Food System Transformation and Gut Microbiota Transition: Evidence on Advancing Obesity, Cardiovascular Diseases, and Cancers-A Narrative Review.Foods (Basel, Switzerland) · 2023Review
- Review
- Review
- Antibiotic resistance in the environment.Nature reviews. Microbiology · 2022Review
- Antibiotic Discovery and Resistance: The Chase and the Race.Antibiotics (Basel, Switzerland) · 2022Review
- Precise strategies for selecting probiotic bacteria in treatment of intestinal bacterial dysfunctional diseases.Frontiers in immunology · 2022Review
- Antibiotic resistance genes and bacterial community on the surfaces of five cultivars of fresh tomatoes.Ecotoxicology (London, England) · 2021Article
- Genetic insights into the dark matter of the mammalian gut microbiota through targeted genome reconstruction.Environmental microbiology · 2021Article
- Article
- Microbial Communities of Meat and Meat Products: An Exploratory Analysis of the Product Quality and Safety at Selected Enterprises in South Africa.Microorganisms · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAncient microbiota information represents an important resource to evaluate bacterial evolution and to explore the biological spread of infectious diseases in history. The soft tissue of frozen mummified humans, such as the Tyrolean Iceman, has been shown to contain bacterial DNA that is suitable for population profiling of the prehistoric bacteria that colonized such ancient human hosts.
resultsHere, we performed a microbial cataloging of the distal gut microbiota of the Tyrolean Iceman, which highlights a predominant abundance of Clostridium and Pseudomonas species. Furthermore, in silico analyses allowed the reconstruction of the genome sequences of five ancient bacterial genomes, including apparent pathogenic ancestor strains of Clostridium perfringens and Pseudomonas veronii species present in the gut of the Tyrolean Iceman.
conclusionsGenomic analyses of the reconstructed C. perfringens chromosome clearly support the occurrence of a pathogenic profile consisting of virulence genes already existing in the ancient strain, thereby reinforcing the notion of a very early speciation of this taxon towards a pathogenic phenotype. In contrast, the evolutionary development of P. veronii appears to be characterized by the acquisition of antibiotic resistance genes in more recent times as well as an evolution towards an ecological niche outside of the (human) gastrointestinal tract.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.