Evidence map›Paper›PMID 28095916›Full record

ArticleMalaria journal2017

Insecticide-treated net effectiveness at preventing Plasmodium falciparum infection varies by age and season.

Andrea G Buchwald, Jenna E Coalson, Lauren M Cohee, Jenny A Walldorf, Nelson Chimbiya, Andy Bauleni, Kondwani Nkanaunena, Andrew Ngwira, John D Sorkin, Don P Mathanga and 2 more

Abstract read
In one paragraph

Article in Malaria journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
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  5. Understanding the Intransigence of Malaria in Malawi.The American journal of tropical medicine and hygiene · 2022
    Article
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  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Andrea G BuchwaldInstitute for Global Health, University of Maryland School of Medicine, 685W, Baltimore St. HSF-1 Room 480, Baltimore, MD, 21201, USA.
Jenna E CoalsonUniversity of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI, 48109, USA.
Lauren M CoheeInstitute for Global Health, University of Maryland School of Medicine, 685W, Baltimore St. HSF-1 Room 480, Baltimore, MD, 21201, USA.
Jenny A WalldorfInstitute for Global Health, University of Maryland School of Medicine, 685W, Baltimore St. HSF-1 Room 480, Baltimore, MD, 21201, USA.
Nelson ChimbiyaUniversity of Malawi College of Medicine, Chichiri, Private Bag 360, Blantyre, Malawi.
Andy BauleniUniversity of Malawi College of Medicine, Chichiri, Private Bag 360, Blantyre, Malawi.
Kondwani NkanaunenaUniversity of Malawi College of Medicine, Chichiri, Private Bag 360, Blantyre, Malawi.
Andrew NgwiraUniversity of Malawi College of Medicine, Chichiri, Private Bag 360, Blantyre, Malawi.
John D SorkinInstitute for Global Health, University of Maryland School of Medicine, 685W, Baltimore St. HSF-1 Room 480, Baltimore, MD, 21201, USA.
Don P MathangaUniversity of Malawi College of Medicine, Chichiri, Private Bag 360, Blantyre, Malawi.
Terrie E TaylorDepartment of Osteopathic Medicine, Michigan State University, West Fee Hall, 909 Fee Road, Room B305, East Lansing, MI, 48824, USA.
Miriam K LauferInstitute for Global Health, University of Maryland School of Medicine, 685W, Baltimore St. HSF-1 Room 480, Baltimore, MD, 21201, USA. mlaufer@medicine.umaryland.edu.

Funding

The role of monocytes in the pathology of severe malaria.U19AI089683 · NIAID · MICHIGAN STATE UNIVERSITY · PI MATHANGA, DON P, TAYLOR, TERRIE ELLEN · 2010 to 2023
$21.4M
FELLOWSHIP TRAINING PROGRAM IN VACCINOLOGYT32AI007524 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Marcelo B. Sztein · 1997 to 2026
$6.4M
Mentoring in patient-oriented research in global healthK24AI114996 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI LAUFER, MIRIAM K. · 2016 to 2025
$1.6M
NIAID NIH HHS K24 AI114996NIAID NIH HHS T32 AI007524NIAID NIH HHS U19 AI089683
6 · The paper itself

Abstract

backgroundAfter increasing coverage of malaria interventions, malaria prevalence remains high in Malawi. Previous studies focus on the impact of malaria interventions among children under 5 years old. However, in Malawi, the prevalence of infection is highest in school-aged children (SAC), ages 5 to 15 years. This study examined the interaction between age group and insecticide-treated net (ITN) use for preventing individual and community-level infection in Malawi.

methodsSix cross-sectional surveys were conducted in the rainy and dry seasons in southern Malawi from 2012 to 2014. Data were collected on household ITN usage and demographics. Blood samples for detection of Plasmodium falciparum infection were obtained from all household members present and over 6 months of age. Generalized linear mixed models were used to account for clustering at the household and community level.

resultsThere were 17,538 observations from six surveys. The association between ITN use and infection varied by season in SAC, but not in other age groups. The adjusted odds ratio (OR) for infection comparing ITN users to non-users among SAC in the rainy season and dry season was 0.78 (95% CI 0.56, 1.10) and 0.51 (0.35, 0.74), respectively. The effect of ITN use did not differ between children under five and adults. Among all non-SACs the OR for infection was 0.78 (0.64, 0.95) in those who used ITNs compared to those that did not. Community net use did not protect against infection.

conclusionsProtection against infection with ITN use varies by age group and season. Individual estimates of protection are moderate and a community-level effect was not detected. Additional interventions to decrease malaria prevalence are needed in Malawi.

Indexed as

AdolescentAdultAgedAged, 80 and overAge FactorsChildChild, PreschoolCross-Sectional StudiesDisease Transmission, InfectiousFemaleHealth Services ResearchHumansInfantInfant, NewbornInsecticide-Treated BednetsMalaria, FalciparumInsecticide-treated netsMalawiPlasmodium falciparumSchool-aged childrenUniversal distribution campaign

Identifiers

PMID28095916
PMCPMC5240228

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.