Trial reportBMC pediatrics2017
Comparison of developmental milestone attainment in early treated HIV-infected infants versus HIV-unexposed infants: a prospective cohort study.
Trial report in BMC pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00428116 (Optimizing Pediatric HIV-1 Treatment, Nairobi, Kenya), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Optimizing Pediatric HIV-1 Treatment, Nairobi, Kenya (0-4.5 Month Randomized Controlled Trial)
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neuropsychiatric Outcomes in Children and Adolescents With Perinatally Acquired HIV: A Systematic Review and Meta-Analysis.Journal of acquired immune deficiency syndromes (1999) · 2025Pooled it
- Major Factors Contributing to Positive and Negative Childbirth Experiences in Pregnant Women Living with HIV.Behavioral sciences (Basel, Switzerland) · 2025Article
- The Pathogenesis of Cytomegalovirus and Other Viruses Associated with Hearing Loss: Recent Updates.Viruses · 2023Review
- Neurodevelopment in early treated HIV-infected infants participating in a developmental stimulation programme compared with controls.Child: care, health and development · 2021Article
- Neurocognitive Complications of Pediatric HIV Infections.Current topics in behavioral neurosciences · 2021Article
- Congenital Cytomegalovirus and Human Immunodeficiency Virus: Effects on Hearing, Speech and Language Development, and Clinical Outcomes in Children.Frontiers in pediatrics · 2021Review
- Home- and Clinic-Based Pediatric HIV Index Case Testing in Kenya: Uptake, HIV Prevalence, Linkage to Care, and Missed Opportunities.Journal of acquired immune deficiency syndromes (1999) · 2020Article
- Brief Report: Diagnostic Accuracy of Oral Mucosal Transudate Tests Compared with Blood-Based Rapid Tests for HIV Among Children Aged 18 Months to 18 Years in Kenya and Zimbabwe.Journal of acquired immune deficiency syndromes (1999) · 2019Article
- Brain structure of perinatally HIV-infected patients on long-term treatment: A systematic review.Neurology. Clinical practice · 2019Review
- Risk and protective factors for child development: An observational South African birth cohort.PLoS medicine · 2019Observational
- High Plasma Soluble CD163 During Infancy Is a Marker for Neurocognitive Outcomes in Early-Treated HIV-Infected Children.Journal of acquired immune deficiency syndromes (1999) · 2019Article
- Low risk of neurodevelopmental impairment among perinatally acquired HIV-infected preschool children who received early antiretroviral treatment in Thailand.Journal of the International AIDS Society · 2019Article
- Neurodevelopment at 11 months after starting antiretroviral therapy within 3 weeks of life.Southern African journal of HIV medicine · 2019Article
- Implications of Combined Exposure to Household Air Pollution and HIV on Neurocognition in Children.International journal of environmental research and public health · 2018Article
- Gross motor developmental delay in human immunodeficiency virus-infected children under 2 years of age.Annals of African medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundInfant HIV infection is associated with delayed milestone attainment. The extent to which effective antiretroviral therapy (ART) prevents these delays is not well defined.
methodsAges at attainment of milestones were compared between HIV-infected (initiated ART by age <5 months), and HIV-unexposed uninfected (HUU) infants. Kaplan Meier analyses were used to estimate and compare (log-rank tests) ages at milestones between groups. Adjusted analyses were performed using Cox proportional hazards models.
resultsSeventy-three HIV-infected on ART (median enrollment age 3.7 months) and 92 HUU infants (median enrollment age 1.6 months) were followed prospectively. HIV-infected infants on ART had delays in developmental milestone attainment compared to HUU: median age at attainment of sitting with support, sitting unsupported, walking with support, walking unsupported, monosyllabic speech and throwing toys were each delayed (all p-values <0.0005). Compared with HUU, the subset of HIV-infected infants with both virologic suppression and immune recovery at 6 months had delays for speech (delay: 2.0 months; P = 0.0002) and trend to later walking unsupported. Among HIV-infected infants with poor 6-month post-ART responses (lacking viral suppression and immune recovery) there were greater delays versus HUU for: walking unsupported (delay: 4.0 months; P = 0.0001) and speech (delay: 5.0 months; P < 0.0001).
conclusionsHIV infected infants with viral suppression on ART had better recovery of developmental milestones than those without suppression, however, deficits persisted compared to uninfected infants. Earlier ART may be required for optimized cognitive outcomes in perinatally HIV-infected infants.
trial registrationNCT00428116 ; January 22, 2007.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.