Evidence map›Paper›PMID 28095801›Full record

Trial reportBMC pregnancy and childbirth2017

Providing lipid-based nutrient supplement during pregnancy does not reduce the risk of maternal P falciparum parasitaemia and reproductive tract infections: a randomised controlled trial.

Minyanga Nkhoma, Per Ashorn, Ulla Ashorn, Kathryn G Dewey, Austrida Gondwe, John Mbotwa, Stephen Rogerson, Steve M Taylor, Kenneth Maleta

Registry-linked trialOpen access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC pregnancy and childbirth, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01239693 (A Research Plan for a Randomised, Single-blind, Parallel Group Controlled Trial in Rural Malawi, Testing the Health Effects of Supplementing Maternal Diet During Pregnancy and Lactation and Infant Diet From 6 to 18 Months of Age With High-energy, Micronutrient Fortified Lipid-based Nutrient Supplements), which is not on this map. Cited by 6 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 3 pooled it
3.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01239693 phase3active not recruitingnot on this map

A Research Plan for a Randomised, Single-blind, Parallel Group Controlled Trial in Rural Malawi, Testing the Health Effects of Supplementing Maternal Diet During Pregnancy and Lactation and Infant Diet From 6 to 18 Months of Age With High-energy, Micronutrient Fortified Lipid-based Nutrient Supplements (LNS)

TypeinterventionalSponsorTampere UniversityRan2011 to 2027Enrolled1,391ConditionsInfant Malnutrition, Malnutrition in PregnancyArmsIFA, MMN, LNS
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 3 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Multiple-micronutrient supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2019
    Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Minyanga NkhomaUniversity of Tampere School of Medicine, University of Tampere, Arvo building, FI-33014, Tampere, Finland.
Per AshornUniversity of Tampere School of Medicine, University of Tampere, Arvo building, FI-33014, Tampere, Finland.
Ulla AshornUniversity of Tampere School of Medicine, University of Tampere, Arvo building, FI-33014, Tampere, Finland.
Kathryn G DeweyDepartment of Nutrition, University of California, One Shields Ave., Davis, CA, 95616-8669, USA.
Austrida GondweUniversity of Tampere School of Medicine, University of Tampere, Arvo building, FI-33014, Tampere, Finland.
John MbotwaSchool of Public Health and Family Medicine, College of Medicine, Mahatma Gandhi Road, Blantyre, Malawi.
Stephen RogersonDepartment of Medicine at the Peter Doherty Institute, 792 Elizabeth Street, Melbourne, VIC, 3000, Australia.
Steve M TaylorDivision of Infectious Diseases and International Health, Duke University Medical Center, Box 102359 DUMC, Durham, NC, 27705, USA.
Kenneth MaletaSchool of Public Health and Family Medicine, College of Medicine, Mahatma Gandhi Road, Blantyre, Malawi. kmaleta@medcol.mw.
Tampere University · FITampere University · FIDuke Medical Center · USPeter Doherty Institute · AUUniversity of California, Davis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMaternal infections are associated with maternal and foetal adverse outcomes. Nutrient supplementation during pregnancy may reduce the occurrence of infections by improving maternal immunity. We aimed to investigate the impact of small-quantity lipid-based nutrient supplement (SQ-LNS) on the occurrence of Plasmodium falciparum parasitaemia during pregnancy and trichomoniasis, vaginal candidiasis and urinary tract infection (UTI) after delivery.

methodsPregnant Malawian women enrolled in the iLiNS-DYAD trial receiving daily supplementation with SQ-LNS, multiple micronutrients (MMN) or iron & folic acid (IFA) from <20 gestation weeks (gw) were assessed for P. falciparum parasitaemia at 32 gw using rapid diagnostic testing (RDT), at 36 gw using polymerase chain reaction (PCR) and at delivery using both RDT and PCR; and at one week after delivery for trichomoniasis and vaginal candidiasis using wet mount microscopy and for UTI using urine dipstick analysis. The prevalence of each infection by intervention group was estimated at the prescribed time points and the global null hypothesis was tested using logistic regression. Adjusted analyses were performed using preselected covariates.

resultsThe prevalence of P. falciparum parasitaemia was 10.7% at 32 gw, 9% at 36 gw, and 8.3% by RDT and 20.2% by PCR at delivery. After delivery the prevalence of trichomoniasis was 10.5%, vaginal candidiasis was 0.5%, and UTI was 3.1%. There were no differences between intervention groups in the prevalence of any of the infections.

conclusionIn this population, SQ-LNS did not influence the occurrence of maternal P. falciparum parasitaemia, trichomoniasis, vaginal candidiasis or UTI.

trial registrationIdentifier: NCT01239693 (10 November 2010).

Indexed as

Dietary SupplementsAdultAnimalsFemaleGestational AgeHumansLipidsMalaria, FalciparumMicronutrientsParasitemiaPlasmodium falciparumPregnancyPregnancy Complications, InfectiousPregnancy Complications, ParasiticReproductive Tract InfectionsLipidsMicronutrientsMicronutrientsPlasmodium falciparumPregnancyReproductive tract infectionsUrinary tract infection

Identifiers

PMID28095801
PMCPMC5240436
OpenAlexW2574726876

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.