Evidence map›Paper›PMID 28095795›Full record

Trial reportBMC anesthesiology2017

Intrathecal magnesium sulfate does not reduce the ED

Fei Xiao, Wenping Xu, Ying Feng, Feng Fu, Xiaomin Zhang, Yinfa Zhang, Lizhong Wang, Xinzhong Chen

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fei XiaoDepartment of Anesthesia, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Wenping XuDepartment of Anesthesia, Jiaxing Maternity and Child Care Hospital, Jiaxing, Zhejiang, China.
Ying FengDepartment of Anesthesia, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Feng FuDepartment of Anesthesia, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Xiaomin ZhangDepartment of Anesthesia, Jiaxing Maternity and Child Care Hospital, Jiaxing, Zhejiang, China.
Yinfa ZhangDepartment of Anesthesia, Jiaxing Maternity and Child Care Hospital, Jiaxing, Zhejiang, China.
Lizhong WangDepartment of Anesthesia, Jiaxing Maternity and Child Care Hospital, Jiaxing, Zhejiang, China.
Xinzhong ChenDepartment of Anesthesia, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China. chenxinz@zju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAddition of intrathecal magnesium sulfate to local anesthetics has been reported to potentiate spinal anesthesia and prolong analgesia in parturients. The current study was to determine whether intrathecal magnesium sulfate would reduce the dose of hyperbaric bupivacaine in spinal anesthesia with bupivacaine and sufentanil for cesarean delivery.

methodsSixty healthy parturients undergoing scheduled cesarean delivery were randomly assigned to receive spinal anesthesia with 0.5% hyperbaric bupivacaine and 5 μg sufentanil with either 0.9% sodium chloride (Control group) or 50% magnesium sulfate (50 mg) (Magnesium group). Effective anesthesia was defined as a bilateral T

resultsThere was no significant difference in the ED

conclusionsIntrathecal magnesium sulfate (50 mg) did not reduce the dose requirement of intrathecal bupivacaine, but can extend the duration of spinal anesthesia with no obvious additional side effects.

trial registrationThis study was registered with Chinese Clinical Trial Registry (ChiCTR) on 15 Jul. 2014 and was given a trial ID number ChiCTR-TRC- 14004954 .

Indexed as

AdultAnesthesia, ObstetricalAnesthesia, SpinalAnesthetics, LocalBupivacaineCesarean SectionDose-Response Relationship, DrugDouble-Blind MethodFemaleHumansInjections, SpinalMagnesium SulfateProspective StudiesYoung AdultAnesthetics, LocalBupivacaineMagnesium SulfateAnesthesiaCesarean deliveryMagnesium sulfateSpinal

Identifiers

PMID28095795
PMCPMC5240204

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.