Evidence map›Paper›PMID 28095612›Full record

ReviewGenesis (New York, N.Y. : 2000)2017

Xenopus laevis as a model system to study cytoskeletal dynamics during axon pathfinding.

Paula G Slater, Laurie Hayrapetian, Laura Anne Lowery

Open access · greenAbstract readReview
In one paragraph

Review in Genesis (New York, N.Y. : 2000), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Special Issue "Neurobiology of Protein Synuclein".International journal of molecular sciences · 2024
    Article
  2. Synuclein Analysis in AdultInternational journal of molecular sciences · 2022
    Article
  3. Review
  4. Article
  5. Profilin choreographs actin and microtubules in cells and cancer.International review of cell and molecular biology · 2020
    Article
  6. Characterization of Xenopus laevis guanine deaminase reveals new insights for its expression and function in the embryonic kidney.Developmental dynamics : an official publication of the American Association of Anatomists · 2019
    Article
  7. The Many Faces ofFrontiers in physiology · 2019
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Paula G SlaterDepartment of Biology, Boston College, Chestnut Hill, Massachusetts.
Laurie HayrapetianDepartment of Biology, Boston College, Chestnut Hill, Massachusetts.
Laura Anne LoweryDepartment of Biology, Boston College, Chestnut Hill, Massachusetts.
Boston College · US

Funding

Elucidating mechanistic connections between guidance signaling, microtubule regulation, and growth cone steering: Diversity SupplementR01MH109651 · NIMH · BOSTON MEDICAL CENTER · PI Laura Anne LOWERY · 2016 to 2026
$4.3M
Function of Microtubule Plus-End-Tracking Proteins in the Neuronal Growth ConeR00MH095768 · NIMH · BOSTON COLLEGE · PI LOWERY, LAURA ANNE · 2014 to 2016
$747k
NIMH NIH HHS R00 MH095768NIMH NIH HHS R01 MH109651
6 · The paper itself

Abstract

The model system, Xenopus laevis, has been used in innumerable research studies and has contributed to the understanding of multiple cytoskeletal components, including actin, microtubules, and neurofilaments, during axon pathfinding. Xenopus developmental stages have been widely characterized, and the Xenopus genome has been sequenced, allowing gene expression modifications through exogenous molecules. Xenopus cell cultures are ideal for long periods of live imaging because they are easily obtained and maintained, and they do not require special culture conditions. In addition, Xenopus have relatively large growth cones, compared to other vertebrates, thus providing a suitable system for imaging cytoskeletal components. Therefore, X. laevis is an ideal model organism in which to study cytoskeletal dynamics during axon pathfinding.

Indexed as

ActinsAnimalsAxon GuidanceAxonsCytoskeletonGrowth ConesMicrotubule-Associated ProteinsXenopus laevisActinsMicrotubule-Associated Proteinscytoskeletongrowth conemicrotubule dynamics

Identifiers

PMID28095612
PMCPMC5276718
OpenAlexW2575333629

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.