ArticlePloS one2017
Pro-Inflammatory Cytokine Levels in HIV Infected and Uninfected Pregnant Women with and without Preeclampsia.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic accuracy of NLR, MLR, PLR, SII, and SIRI for predicting major adverse maternal outcomes in preeclampsia: A systematic review.The Journal of international medical research · 2026Pooled it
- Protein C Levels in Human Immunodeficiency Virus-Infected Women with and Without Pre-Eclampsia in South Africa.Biomedicines · 2026Article
- Maternal inflammation disrupts transplacental antibody transfer in pregnant individuals with and without HIV.Frontiers in immunology · 2026Article
- Short- and Long-Term Clinical Outcomes of Preeclampsia in Women and Their Neonates in Pregnancies With and Without HIV Infection.International journal of hypertension · 2026Review
- Maternal and early-life longitudinal cytokine profiles in a South African birth cohort: the impact of HIV.bioRxiv : the preprint server for biology · 2025Article
- Maternal and child immune profiles are associated with neurometabolite measures of early-life neuroinflammation in children who are HIV-exposed and uninfected: a South African birth cohort.Wellcome open research · 2025Article
- Review
- Distinct cytokine profiles in late pregnancy in Ugandan people with HIV.Scientific reports · 2024Article
- Genetic Appraisal of RAAS-Associated SNPs: REN (rs16853055), AGT (rs3789678) and ACE (rs4305) in Preeclamptic Women Living with HIV Infection.Current hypertension reports · 2024Review
- High sensitivity C-reactive protein in pre-eclamptic women living with HIV at a tertiary hospital in Zambia: a preliminary study.The Pan African medical journal · 2024Article
- Immune checkpoint molecules B7-1 and B7-H1 as predictive markers of pre-eclampsia: A case-control study in a Ghana.Immunity, inflammation and disease · 2024Article
- Is the central complement component C3 altered in the synergy of HIV infection and preeclampsia?European journal of obstetrics & gynecology and reproductive biology: X · 2023Article
- Effects of Antimicrobial Peptides Gal-13 on the Growth Performance, Intestinal Microbiota, Digestive Enzyme Activities, Intestinal Morphology, Antioxidative Activities, and Immunity of Broilers.Probiotics and antimicrobial proteins · 2023Article
- The effectiveness of the Congo Red Dot paper test in hypertensive disorders of pregnancy: A systematic review and meta-analysis.Frontiers in reproductive health · 2023Review
- Maternal ART throughout gestation prevents caudate volume reductions in neonates who are HIV exposed but uninfected.Frontiers in neuroscience · 2023Article
- Association between preeclampsia and HIV: a case-control study in urban South Africa.AJOG global reports · 2022Article
- Study of Treatment and Reproductive Outcomes Among Reproductive-Age Women With HIV Infection in the Southern United States: Protocol for a Longitudinal Cohort Study.JMIR research protocols · 2021Article
- Cytokine profiles in highly active antiretroviral treatment non-adherent, adherent and naive HIV-1 infected patients in Western Kenya.African health sciences · 2021Article
- HIV Associated Preeclampsia: A Multifactorial Appraisal.International journal of molecular sciences · 2021Review
- Maternal HIV infection is associated with distinct systemic cytokine profiles throughout pregnancy in South African women.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
introductionPreeclampsia and HIV/AIDS are inflammatory conditions that contribute significantly to adverse maternal and foetal outcomes. The immune reconstitution effects of HAART on inflammatory mediators has not been adequately studied in pregnancy and may impact on the inflammatory cytokine network in women with co-morbid preeclampsia. Our study evaluated changes in pro-inflammatory cytokines IL-2, TNF-α, IFN-γ and IL-6 in HIV infected preeclamptic women on HAART.
methodsA prospective experimental study was conducted at Prince Mshiyeni Memorial Hospital between July 2013 and September 2014. One hundred and ninety three pregnant women were recruited into 4 groups: uninfected normotensive (50; 26%), infected normotensive (45; 23%), uninfected preeclamptic (53; 28%) and infected preeclamptic women (45; 23%). Serum levels of cytokines TNF-α, IFN- γ, IL-2 and IL-6 were determined using commercially available kits and a Cytometric Bead Array (CBA). Comparative data was recorded and analysed descriptively.
resultsIn the control groups (normotensive), significantly lower values were found in IL-2 (p = 0.010), TNF-α (p = 0.045), and IL-6 (p = 0.005); and a non-significant decrease was observed in IFN-γ (p = 0.345) in HIV infected women on HAART compared to uninfected controls. In the experimental group (preeclamptic) women, significantly reduced levels were observed in IL-2 and TNF-α (p = 0.001; p = 0.000) and non-significant decreases were observed in IFN-γ and IL-6 (p = 0.023; p = 0.086) in HIV infected women on HAART compared with uninfected preeclamptic women. Non-significant differences were observed between uninfected preeclamptic and normotensive women.
conclusionIn uncomplicated/normotensive pregnancies, HIV/HAART is associated with significant decreases in IL-2, TNF-α and IL-6, and in preeclamptic women significant decreases in IL-2 and TNF-α were observed. These findings suggest that HIV/HAART impacts on pro-inflammatory cytokines in women with co-morbid preeclampsia. This provides a platform for further research on immune reconstitution effects of HAART during pregnancy, and the development of potential immune modulation therapies for the management of preeclampsia.
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