SynthesisPloS one2017
Brain Parenchymal Fraction in Healthy Adults-A Systematic Review of the Literature.
Synthesis in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Air pollution in relation to brain health indicators and global cognitive functioning in people with cardiovascular disorders along the heart-brain axis.Cerebral circulation - cognition and behavior · 2026Article
- Measurement characteristics and genome-wide correlates of lifetime brain atrophy estimated from a single MRI.Nature communications · 2025Article
- Brain health operationalized as brain parenchymal fraction impacts stroke severity both in acute phase and 3 months post stroke.Brain communications · 2025Article
- Longevity of a Brain-Computer Interface for Amyotrophic Lateral Sclerosis.The New England journal of medicine · 2024Article
- Age-related decline in cerebral oxygen consumption in multiple sclerosis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- A multi-site study on sex differences in cortical thickness in non-demented Parkinson's disease.NPJ Parkinson's disease · 2024Article
- Brain volume is a better biomarker of outcomes in ischemic stroke compared to brain atrophy.Frontiers in stroke · 2024Article
- Comparison of models for stroke-free survival prediction in patients with CADASIL.Scientific reports · 2023Observational
- Improvement of an External Predictive Model Based on New Information Using a Synthetic Data Approach: Application to CADASIL.Neurology. Genetics · 2023Article
- Soluble Epoxide Hydrolase Derived Linoleic Acid Oxylipins, Small Vessel Disease Markers, and Neurodegeneration in Stroke.Journal of the American Heart Association · 2023Article
- Brain and cognitive ageing: The present, and some predictions (…about the future).Aging brain · 2022Article
- Head CT: Toward Making Full Use of the Information the X-Rays Give.AJNR. American journal of neuroradiology · 2021Review
- Pediatric Head CT: Automated Quantitative Analysis with Quantile Regression.AJNR. American journal of neuroradiology · 2021Article
- Aging and the Brain: A Quantitative Study of Clinical CT Images.AJNR. American journal of neuroradiology · 2020Article
- Ontario Neurodegenerative Disease Research Initiative (ONDRI): Structural MRI Methods and Outcome Measures.Frontiers in neurology · 2020Article
- Novel multi-linear quantitative brain volume formula for manual radiological evaluation of brain atrophy.European journal of radiology open · 2020Article
- The Human Brain Representation of Odor Identification in Amnestic Mild Cognitive Impairment and Alzheimer's Dementia of Mild Degree.Frontiers in neurology · 2020Article
- Associations of Changes in Cardiorespiratory Fitness and Symptoms of Anxiety and Depression With Brain Volumes: The HUNT Study.Frontiers in behavioral neuroscience · 2019Article
- Diffusion kurtosis and quantitative susceptibility mapping MRI are sensitive to structural abnormalities in amyotrophic lateral sclerosis.NeuroImage. Clinical · 2019Article
- Midline Shift is Unrelated to Subjective Pupillary Reactivity Assessment on Admission in Moderate and Severe Traumatic Brain Injury.Neurocritical care · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain atrophy is an important feature of many neurodegenerative disorders. It can be described in terms of change in the brain parenchymal fraction (BPF). In order to interpret the BPF in disease, knowledge on the BPF in healthy individuals is required. The aim of this study was to establish a normal range of values for the BPF of healthy individuals via a systematic review of the literature. The databases PubMed and Scopus were searched and 95 articles, including a total of 9269 individuals, were identified including the required data. We present values of BPF from healthy individuals stratified by age and post-processing method. The mean BPF correlated with mean age and there were significant differences in age-adjusted mean BPF between methods. This study contributes to increased knowledge about BPF in healthy individuals, which may assist in the interpretation of BPF in the setting of disease. We highlight the differences between post-processing methods and the need for a consensus gold standard.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.