Evidence map›Paper›PMID 28095456›Full record

ArticlePloS one2017

A Rasch Analysis of the Charcot-Marie-Tooth Neuropathy Score (CMTNS) in a Cohort of Charcot-Marie-Tooth Type 1A Patients.

Wenjia Wang, Mickaël Guedj, Viviane Bertrand, Julie Foucquier, Elisabeth Jouve, Daniel Commenges, Cécile Proust-Lima, Niall P Murphy, Olivier Blin, Laurent Magy and 2 more

Abstract read
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Charcot-Marie-Tooth Disease Type 1A: Influence of Body Mass Index on Nerve Conduction Studies and on the Charcot-Marie-Tooth Examination Score.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wenjia WangInserm U1219, Université de Bordeaux, Bordeaux, Aquitaine, France.ORCID http://orcid.org/0000-0003-0256-059X
Mickaël GuedjPharnext, Issy-Les-Moulineaux, France.
Viviane BertrandPharnext, Issy-Les-Moulineaux, France.
Julie FoucquierPharnext, Issy-Les-Moulineaux, France.
Elisabeth JouveCIC-CPCET, Service de Pharmacologie Clinique et Pharmacovigilance, AP-HM, Aix Marseille Université, Marseille, France.
Daniel CommengesInserm U1219, Université de Bordeaux, Bordeaux, Aquitaine, France.
Cécile Proust-LimaInserm U1219, Université de Bordeaux, Bordeaux, Aquitaine, France.
Niall P MurphyPharnext, Issy-Les-Moulineaux, France.
Olivier BlinCIC-CPCET, Service de Pharmacologie Clinique et Pharmacovigilance, AP-HM, Aix Marseille Université, Marseille, France.
Laurent MagyCentre de Référence Neuropathies Périphérique Rares, CHU de Limoges - Hôpital Dupuytren, Limoges, France.
Daniel CohenPharnext, Issy-Les-Moulineaux, France.
Shahram AttarianAix Marseille Université, INSERM, GMGF, Marseille, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Charcot-Marie-Tooth Neuropathy Score (CMTNS) was developed as a main efficacy endpoint for application in clinical trials of Charcot-Marie-Tooth disease type 1A (CMT1A). However, the sensitivity of the CMTNS for measuring disease severity and progression in CMT1A patients has been questioned. Here, we applied a Rasch analysis in a French cohort of patients to evaluate the psychometrical properties of the CMTNS. Overall, our analysis supports the validity of the CMTNS for application to CMT1A patients though with some limitations such as certain items of the CMTNS being more suitable for moderate to severe forms of the disease, and some items being disordered. We suggest that additional items and/or categories be considered to better assess mild-to-moderate patients.

Indexed as

Models, TheoreticalOutcome Assessment, Health CarePsychometricsSeverity of Illness IndexAdolescentAdultAgedCharcot-Marie-Tooth DiseaseClinical Trials, Phase II as TopicCohort StudiesFemaleHumansMaleMiddle AgedYoung Adult

Identifiers

PMID28095456
PMCPMC5240958

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.