Evidence map›Paper›PMID 28095426›Full record

SynthesisPloS one2017

Health Outcomes of Sarcopenia: A Systematic Review and Meta-Analysis.

Charlotte Beaudart, Myriam Zaaria, Françoise Pasleau, Jean-Yves Reginster, Olivier Bruyère

8 registry-linked trialsAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 8 registered trials, which are not on this map. Cited by 651 papers, 20 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
651citing papers in PubMed, 20 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03553147 naunknown statusnot on this mapstarted 2018, after this paper: background citation

Evaluation of the SARC-F Score as a Screening Tool for Undernutrition in a Geriatric Population

TypeinterventionalSponsorUniversity Hospital, Clermont-FerrandRan2018 to 2019Enrolled260ConditionsSarcopenia, DenutritionArmsSARC-F score, handgrip test and impedancemetry
NCT04028206 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Elastic-band Resistance Exercise or Vibration Treatment With Hydroxymethylbutyrate (HMB) Supplement for Sarcopenic Older People

TypeinterventionalSponsorChinese University of Hong KongRan2019 to 2023Enrolled144ConditionsSarcopeniaArmsHydroxymethylbutyrate, Low-magnitude High Frequency Vibration (LMHFV), Elastic-band Exercise
NCT05869487 narecruitingnot on this mapstarted 2023, after this paper: background citation

Evaluation of a Diagnostic Method: Calf Circumference Versus X-ray Absorptiometry in the Diagnosis of Sarcopenia in Elderly Hospitalized Participants

TypeinterventionalSponsorCentre Hospitalier Régional d'OrléansRan2023 to 2027Enrolled298ConditionsSarcopeniaArmsDual-energy X-ray absorptiometry
NCT05982067 naunknown statusnot on this mapstarted 2023, after this paper: background citation

The Utility of MIndfulness-based Physical Exercise Program (MIPE Program) for Community-dwelling Older People With Sarcopenia: a Pilot Randomised Controlled Trial

TypeinterventionalSponsorThe Hong Kong Polytechnic UniversityRan2023 to 2023Enrolled60ConditionsSarcopeniaArmsmindfulness-based phsycial exercise intervention, health education
NCT06548984 nanot yet recruitingnot on this mapstarted 2024, after this paper: background citation

Respiratory Sarcopenia in Older Adults: Prevalence, Associated Factors and Response to an Exercise Program

TypeinterventionalSponsorFelipe León MorillasRan2024 to 2025Enrolled50ConditionsSarcopeniaArmsdiaphragmatic exercises, Respiratory muscle training
NCT06829121 completednot on this mapstarted 2020, after this paper: background citation

Ultrasound-based Morphometry for the Development of Diagnostic and Prognostic Markers in Current and Chronic Diseases

Typeobservational_patient_registrySponsorUniversitatsmedizin Mainz - 1. Medizinische KlinikRan2020 to 2024Enrolled900ConditionsUltrasound, Sarcopenia, Muscle LossArmsUltrasound
NCT06829290 recruitingnot on this mapstarted 2024, after this paper: background citation

Influence of Sarcopenia on the Course of the Diseases - Measured Using Ultrasound and Biochemical Markers

Typeobservational_patient_registrySponsorUniversitatsmedizin Mainz - 1. Medizinische KlinikRan2024 to 2028Enrolled200ConditionsLiver Cirrhosis, Cancer, Cachexia, SarcopeniaArmsUltrasound
NCT07275996 naactive not recruitingnot on this mapstarted 2026, after this paper: background citation

Effects of Creatine Monohydrate and β-Hydroxy-β-Methylbutyrate Supplementation Combined With Multicomponent Exercise on Physical Performance, Cognition and Quality of Life in Institutionalized Older Adults: A Randomized Double-Blind Parallel-Group Trial

TypeinterventionalSponsorUniversidad de BurgosRan2026 to 2027Enrolled50ConditionsFrailty, Sarcopenia, Aging, Malnutrition ElderlyArmsPlacebo (Cellulose), Creatine Monohydrate, Multicomponent Exercise Program, β-Hydroxy-β-Methylbutyrate (HMB)
3 · Its place in the literature

Who cites it

651 citing papers in PubMed, 20 syntheses or guidelines pooled it.

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  2. Circulating biomarkers in older adults with and without sarcopenia: a systematic review and meta-analysis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
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  6. Does osteosarcopenia synergistically increase risk for incident falls and fractures? A systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
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  8. How Pragmatic Are Sarcopenia Intervention Studies? A Systematic Review.Journal of cachexia, sarcopenia and muscle · 2026
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591 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Charlotte BeaudartPublic Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium.
Myriam ZaariaAix-Marseille University, School of Medicine, Marseille, France.
Françoise PasleauLife Sciences Library, University of Liège, Liège, Belgium.
Jean-Yves ReginsterPublic Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium.
Olivier BruyèrePublic Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe purpose of this study was to perform a systematic review to assess the short-, middle- and long-term consequences of sarcopenia.

methodsProspective studies assessing the consequences of sarcopenia were searched across different electronic databases (MEDLINE, EMBASE, EBM Reviews, Cochrane Database of Systematic Reviews, EBM Reviews ACP Journal Club, EBM Reviews DARE and AMED). Only studies that used the definition of the European Working Group on Sarcopenia in Older People to diagnose sarcopenia were included. Study selection and data extraction were performed by two independent reviewers. For outcomes reported by three or more studies, a meta-analysis was performed. The study results are expressed as odds ratios (OR) with 95% CI.

resultsOf the 772 references identified through the database search, 17 were included in this systematic review. The number of participants in the included studies ranged from 99 to 6658, and the duration of follow-up varied from 3 months to 9.8 years. Eleven out of 12 studies assessed the impact of sarcopenia on mortality. The results showed a higher rate of mortality among sarcopenic subjects (pooled OR of 3.596 (95% CI 2.96-4.37)). The effect was higher in people aged 79 years or older compared with younger subjects (p = 0.02). Sarcopenia is also associated with functional decline (pooled OR of 6 studies 3.03 (95% CI 1.80-5.12)), a higher rate of falls (2/2 studies found a significant association) and a higher incidence of hospitalizations (1/1 study). The impact of sarcopenia on the incidence of fractures and the length of hospital stay was less clear (only 1/2 studies showed an association for both outcomes).

conclusionSarcopenia is associated with several harmful outcomes, making this geriatric syndrome a real public health burden.

Indexed as

Outcome Assessment, Health CareHospitalizationHumansSarcopenia

Identifiers

PMID28095426
PMCPMC5240970

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

and 2 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.