ArticlePLoS computational biology2017
A General Shear-Dependent Model for Thrombus Formation.
Article in PLoS computational biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 132 citations in OpenAlex.
- Suspended particles for omnidirectional template sacrifice for rapid vascular patterning within engineered tissues.Science advances · 2026Article
- Computational modeling of pro-inflammatory cytokine-enhanced blood coagulation.bioRxiv : the preprint server for biology · 2026Article
- A three-dimensional shear dependent continuum model of platelet aggregation under flow.PLoS computational biology · 2026Article
- Severe Aortic Stenosis Is Associated With Left Atrial Prothrombotic Flow That Persists Despite Valve Replacement.Journal of the American Heart Association · 2026Article
- Computational Modeling of Pro-inflammatory Cytokine-Enhanced Blood Coagulation.Computational and structural biotechnology journal · 2026Article
- A 2D computational model of chemically- and mechanically-induced platelet plug formation.Biomechanics and modeling in mechanobiology · 2025Article
- Multiscale simulations that incorporate patient-specific neural network models of platelet calcium signaling predict diverse thrombotic outcomes under flow.PLoS computational biology · 2025Article
- Cardiomyopathy and thrombogenesis in cats through left atrial morphological and fluid dynamics analysis.Scientific reports · 2025Article
- Mechanisms of aortic dissection: From pathological changes to experimental andProgress in materials science · 2025Article
- Sacrificial Templating for Accelerating Clinical Translation of Engineered Organs.ACS biomaterials science & engineering · 2025Review
- Coagulo-Net: Enhancing the mathematical modeling of blood coagulation using physics-informed neural networks.Neural networks : the official journal of the International Neural Network Society · 2024Article
- Modeling Fibrin Accumulation on Flow-Diverting Devices for Intracranial Aneurysms.International journal for numerical methods in biomedical engineering · 2024Article
- Investigating clot-flow interactions by integrating intravital imaging with in silico modeling for analysis of flow, transport, and hemodynamic forces.Scientific reports · 2024Article
- Investigating the pathophysiology and evolution of internal carotid dissection: a fluid-structure interaction simulation study.Frontiers in neurology · 2024Article
- Efficient multi-fidelity computation of blood coagulation under flow.PLoS computational biology · 2023Article
- Image-based flow simulation of platelet aggregates under different shear rates.PLoS computational biology · 2023Article
- Biomechanical activation of blood platelets via adhesion to von Willebrand factor studied with mesoscopic simulations.Biomechanics and modeling in mechanobiology · 2023Article
- von Willebrand factor unfolding mediates platelet deposition in a model of high-shear thrombosis.Biophysical journal · 2022Article
- A fibrin enhanced thrombosis model for medical devices operating at low shear regimes or large surface areas.PLoS computational biology · 2022Article
- A 1D-3D Hybrid Model of Patient-Specific Coronary Hemodynamics.Cardiovascular engineering and technology · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Modeling the transport, activation, and adhesion of platelets is crucial in predicting thrombus formation and growth following a thrombotic event in normal or pathological conditions. We propose a shear-dependent platelet adhesive model based on the Morse potential that is calibrated by existing in vivo and in vitro experimental data and can be used over a wide range of flow shear rates ([Formula: see text]). We introduce an Eulerian-Lagrangian model where hemodynamics is solved on a fixed Eulerian grid, while platelets are tracked using a Lagrangian framework. A force coupling method is introduced for bidirectional coupling of platelet motion with blood flow. Further, we couple the calibrated platelet aggregation model with a tissue-factor/contact pathway coagulation cascade, representing the relevant biology of thrombin generation and the subsequent fibrin deposition. The range of shear rates covered by the proposed model encompass venous and arterial thrombosis, ranging from low-shear-rate conditions in abdominal aortic aneurysms and thoracic aortic dissections to thrombosis in stenotic arteries following plaque rupture, where local shear rates are extremely high.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.