ArticleBritish journal of cancer2017
Evaluation of treatment-related mortality among paediatric cancer deaths: a population based analysis.
Article in British journal of cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Treatment-related mortality in children with cancer in low-income and middle-income countries: a systematic review and meta-analysis.The Lancet. Oncology · 2023Pooled it
- Analysis of Causes and Risk Factors for Deaths Among Pediatric Oncology Patients: A 20-Year Observation.Cancer management and research · 2026Article
- Disparities in pediatric oncology access and outcomes in the occupied Palestinian territories: a retrospective study from Augusta Victoria Hospital.EClinicalMedicine · 2025Article
- New perspectives on extracorporeal life support: expert teams and precise selection of candidates are transforming pediatric cancer and hematopoietic cell transplantation care.Frontiers in oncology · 2025Article
- Treatment-related mortality in childhood cancer patients - who, when and how much.Acta oncologica (Stockholm, Sweden) · 2024Article
- Treatment-related mortality among children with cancer in Denmark during 2001-2021.Acta oncologica (Stockholm, Sweden) · 2024Article
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- Children's Oncology Group's 2023 blueprint for research: Cancer control and supportive care.Pediatric blood & cancer · 2023Article
- Article
- KIdney aNd blooD prESsure ouTcomes in Childhood Cancer Survivors: Description of Clinical Research Protocol of the KINDEST-CCS Study.Canadian journal of kidney health and disease · 2022Article
- Pediatric hematology/oncology healthcare professional emotional health during COVID-19.Cancer medicine · 2021Article
- Diagnostic discrepancies between antemortem clinical diagnosis and autopsy findings in pediatric cancer patients.Virchows Archiv : an international journal of pathology · 2021Article
- Causes of death in pediatric neuro-oncology: the sickkids experience from 2000 to 2017.Journal of neuro-oncology · 2020Article
- Treatment-related mortality in newly diagnosed pediatric cancer: a population-based analysis.Cancer medicine · 2018Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundObjectives were to describe the proportion of deaths due to treatment-related mortality (TRM) and to identify risk factors and probable causes of TRM among paediatric cancer deaths in a population-based cohort.
methodsWe included children with cancer ⩽18 years diagnosed and treated in Ontario who died between January 2003 and December 2012. Deaths were identified using a provincial registry, the Pediatric Oncology Group of Ontario Networked Information System. Probable causes of TRM were described.
resultsAmong the 964 deaths identified, 821 were included. The median age at diagnosis was 6.6 years (range 0-18.8) and 51.8% had at least one relapse. Of the deaths examined, TRM occurred in 217/821 (26.4%) while 604/821 (73.6%) were due to progressive cancer. Deaths from TRM did not change over time. Using multiple regression, younger age, leukaemia diagnosis and absence of relapse were independently positively associated with TRM. The most common probable causes of TRM were respiratory, infection and haemorrhage.
conclusionsTRM was responsible for 26.4% of deaths in paediatric cancer. Underlying diagnosis, younger age and absence of relapse were associated with TRM and causes of TRM differed by diagnosis group. Future work should evaluate TRM rate and risk factors among newly diagnosed cancer patients.
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