Evidence map›Paper›PMID 28094999›Full record

ArticleNeuropsychology2017

Specificity of executive functioning and processing speed problems in common psychopathology.

Joel T Nigg, Jennifer M Jester, Gillian M Stavro, Ka I Ip, Leon I Puttler, Robert A Zucker

Abstract read
In one paragraph

Article in Neuropsychology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. [Formula: see text] Data-driven profiles of behavior in pediatric medical disorders.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2026
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  7. Changes in processing speed during early abstinence from alcohol dependence.Journal of psychopharmacology (Oxford, England) · 2024
    Article
  8. Article
  9. Processing Speed is Related to the General Psychopathology Factor in Youth.Research on child and adolescent psychopathology · 2023
    Article
  10. Prospective prediction of developing internalizing disorders in ADHD.Journal of child psychology and psychiatry, and allied disciplines · 2023
    Article
  11. Article
  12. Article
  13. The Influence of Processing Speed, Attention, and Inhibition on Texas Functional Living Scale Performance.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Joel T NiggDepartment of Psychiatry, Oregon Health & Science University.
Jennifer M JesterDepartment of Psychiatry, The University of Michigan.
Gillian M StavroDepartment of Psychology, Michigan State University.
Ka I IpDepartment of Psychiatry, The University of Michigan.
Leon I PuttlerDepartment of Psychiatry, The University of Michigan.
Robert A ZuckerDepartment of Psychiatry, The University of Michigan.

Funding

Family Study of Risk for Alcoholism Over the Life CourseR37AA007065 · NIAAA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZUCKER, ROBERT ALPERT · 2003 to 2012
$10.6M
Neurocognitive Risk For Alcoholism Into AdulthoodR01AA012217 · NIAAA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HEITZEG, MARY M, ZUCKER, ROBERT ALPERT · 2000 to 2015
$7.3M
ADHD heterogeneity, mechanisms, and risk profileR37MH059105 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI NIGG, JOEL T · 2014 to 2023
$7.0M
RISK AND COPING IN CHILDREN OF ALCOHOLICSR01AA007065 · NIAAA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HEITZEG, MARY M · 1987 to 2017
$6.1M
NEUROPSYCHOLOGICAL AND FAMILIAL MARKERS FOR CHILD ADHDR01MH059105 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI NIGG, JOEL T · 1999 to 2012
$3.3M
Inhibition and Cognition in Adolescent and Adult ADHDR01MH063146 · NIMH · MICHIGAN STATE UNIVERSITY · PI NIGG, JOEL T · 2001 to 2004
$1.6M
NIAAA NIH HHS R01 AA007065NIAAA NIH HHS R01 AA012217NIAAA NIH HHS R37 AA007065NIMH NIH HHS R01 MH059105NIMH NIH HHS R01 MH063146NIMH NIH HHS R37 MH059105
6 · The paper itself

Abstract

objectiveInterest continues in neuropsychological measures as cross-disorder intermediate phenotypes in understanding psychopathology. A central question concerns their specificity versus generalizability to particular forms of psychopathology, particularly for executive functioning (EF) and response speed. Three conceptual models examining these relationships were tested to clarify this picture at different levels in the diagnostic hierarchy.

methodParticipants (total n = 641, age 18-60) yielded complete structured diagnostic interviews and a neuropsychological test battery comprising measures of executive function, processing speed, and IQ. Repeated measures multivariate analysis of variance, linear regression, and structural equation modeling (SEM) were used to test (a) a specificity model, which proposes that individual disorders are associated with component EF processes and speed; (b) a severity model, which proposes that the total number of comorbid disorders explain poor EF and/or slow speed; and (c) a higher-order dimensional model, which proposes that internalizing versus externalizing disorders are differentially related to EF or speed.

resultsEF effects were best explained by a specificity model, with distinct aspects of EF related to attention deficit hyperactivity disorder versus antisocial substance use disorders. Speed, on the other hand, emerged as a general indicator of externalizing psychopathology in the dimensional model, as well as overall severity of psychopathology in the severity model.

conclusionsGranular approaches are likely to be most productive for linking EF to psychopathology, whereas response speed has underused potential as an endophenotype for psychopathology liability. Results are discussed in terms of an integrated conceptualization of neuropsychological processes and putative neural systems involved in general and specific aspects of psychopathology. (PsycINFO Database Record

Indexed as

Executive FunctionReaction TimeAdolescentAdultAntisocial Personality DisorderAttention Deficit Disorder with HyperactivityFemaleHumansInhibition, PsychologicalIntelligence TestsMaleMemory, Short-TermMental DisordersMiddle AgedNeuropsychological TestsPhenotype

Identifiers

PMID28094999
PMCPMC5408314

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.