ArticleJournal of the American Chemical Society2017
Fe-Catalyzed C-C Bond Construction from Olefins via Radicals.
Article in Journal of the American Chemical Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.
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Who cites it
96 citing papers in PubMed, 421 citations in OpenAlex.
- Cascade MHAT Radical Cyclopentannulation of Skipped Enyne to Access Highly Functionalized Carbocycles.JACS Au · 2026Article
- Flash Communication: Siloxides Promote the Iron-Catalyzed Borylation of Aryl Chlorides.Organometallics · 2026Article
- Chemo-divergent and regioselective branched cross-hydroalkenylation of electron-deficient olefins and vinylarenes directed by (NHC)Ni(II) catalysts.Nature communications · 2026Article
- Enzymatic Metal-Hydrogen Atom Transfer with a Cobalt Protoporphyrin Cofactor.Journal of the American Chemical Society · 2026Article
- Expanding Terpenoid Chemical Space Through Radical-Mediated Remodeling of the 4-nor-(3Z,7E)-Neodolabellane Framework.Chemistry, an Asian journal · 2026Article
- Combining biocatalytic and radical retrosynthesis for efficient chemoenzymatic synthesis of natural products.Chemical Society reviews · 2025Review
- Overcoming Challenges in Small-Ring Transfer: Direct Decarboxylative Hydroalkylation of Alkenes via Iron-Thiol Catalysis.Angewandte Chemie (International ed. in English) · 2025Article
- Asymmetric alkyl-alkyl coupling between electron-deficient and unactivated alkenes to access α-chiral phosphines by Ni catalysis.Science advances · 2025Article
- An Oxygen Walk Approach for C3 Selective Hydroxylation of Pyridines.Synlett : accounts and rapid communications in synthetic organic chemistry · 2025Article
- Substrate-Dependent Hydridic and Radical Reactivity of Triiron Hydride Clusters.Inorganic chemistry · 2025Article
- Enantioselective Access to Decahydroquinolines Bearing a CThe Journal of organic chemistry · 2025Article
- Efficient and modular synthesis of ibogaine and related alkaloids.Nature chemistry · 2025Article
- Metal-Catalyzed Hydrogen Atom Transfer (MHAT) Hydroalkylation with Electron-Deficient Alkynes.Organic letters · 2024Article
- Molecular Complexity-Inspired Synthetic Strategies toward the Calyciphylline A-TypeJournal of the American Chemical Society · 2024Article
- Metal-Hydride C-C Cross-Coupling of Alkenes Through a Double Outer-Sphere Mechanism.The Journal of organic chemistry · 2024Review
- Building Catalytic Reactions One Electron at a Time.Accounts of chemical research · 2024Article
- Total Synthesis of Hypersampsone M.Journal of the American Chemical Society · 2024Article
- 1,3-Difunctionalization of [1.1.1]propellane through iron-hydride catalyzed hydropyridylation.Nature communications · 2024Article
- Directed Hydrogen Atom Transfer for Selective Reactions of Polyenols.Journal of the American Chemical Society · 2024Article
- Fe/Thiol Cooperative Hydrogen Atom Transfer Olefin Hydrogenation: Mechanistic Insights That Inform Enantioselective Catalysis.Journal of the American Chemical Society · 2024Article
36 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
This Article details the development of the iron-catalyzed conversion of olefins to radicals and their subsequent use in the construction of C-C bonds. Optimization of a reductive diene cyclization led to the development of an intermolecular cross-coupling of electronically-differentiated donor and acceptor olefins. Although the substitution on the donor olefins was initially limited to alkyl and aryl groups, additional efforts culminated in the expansion of the scope of the substitution to various heteroatom-based functionalities, providing a unified olefin reactivity. A vinyl sulfone acceptor olefin was developed, which allowed for the efficient synthesis of sulfone adducts that could be used as branch points for further diversification. Moreover, this reactivity was extended into an olefin-based Minisci reaction to functionalize heterocyclic scaffolds. Finally, mechanistic studies resulted in a more thorough understanding of the reaction, giving rise to the development of a more efficient second-generation set of olefin cross-coupling conditions.
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Registered trials
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