ArticleeLife2017
Homeodomain protein Otp affects developmental neuropeptide switching in oxytocin neurons associated with a long-term effect on social behavior.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Social Preference Tests in Zebrafish: A Systematic Review.Frontiers in veterinary science · 2020Pooled it
- Multi-transmitter characteristics and functional specialization of oxytocin neuron subpopulations in zebrafish.The Journal of experimental biology · 2026Article
- Oxytocinergic Signaling in Zebrafish: Translational Perspectives for Autism Spectrum Disorder.Journal of neurochemistry · 2026Review
- Environmental context modulates sociability in ube3a zebrafish mutants via alterations in sensory pathways.Molecular psychiatry · 2026Article
- Development of the neurohypophysis: A major neuroendocrine interface.Journal of neuroendocrinology · 2026Review
- Behavioral and molecular insights into anxiety in ube3a and fmr1 zebrafish models of autism spectrum disorders.Translational psychiatry · 2025Article
- Disrupted diencephalon development and neuropeptidergic pathways in zebrafish with autism-risk mutations.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Glucocorticoid receptor regulates protein chaperone, circadian clock and affective disorder genes in the zebrafish brain.Disease models & mechanisms · 2023Article
- Zebrafish as a model to investigate the CRH axis and interactions with DISC1.Current opinion in endocrine and metabolic research · 2022Review
- Social isolation modulates appetite and avoidance behavior via a common oxytocinergic circuit in larval zebrafish.Nature communications · 2022Article
- Oxytocin receptors influence the development and maintenance of social behavior in zebrafish (Danio rerio).Scientific reports · 2022Article
- Developmental Effects of Oxytocin Neurons on Social Affiliation and Processing of Social Information.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Oxytocin Signaling Acts as a Marker for Environmental Stressors in Zebrafish.International journal of molecular sciences · 2021Article
- Oxytocinergic Feedback Circuitries: An Anatomical Basis for Neuromodulation of Social Behaviors.Frontiers in neural circuits · 2021Article
- The homeodomain transcription factor Orthopedia is involved in development of the Drosophila hindgut.Hereditas · 2020Article
- Splice-specific deficiency of the PTSD-associated gene PAC1 leads to a paradoxical age-dependent stress behavior.Scientific reports · 2020Article
- The fenestrae-associated protein Plvap regulates the rate of blood-borne protein passage into the hypophysis.Development (Cambridge, England) · 2019Article
- Social creatures: Model animal systems for studying the neuroendocrine mechanisms of social behaviour.Journal of neuroendocrinology · 2019Review
- Zebrafish oxytocin neurons drive nocifensive behavior via brainstem premotor targets.Nature neuroscience · 2019Article
- Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proper response to stress and social stimuli depends on orchestrated development of hypothalamic neuronal circuits. Here we address the effects of the developmental transcription factor orthopedia (Otp) on hypothalamic development and function. We show that developmental mutations in the zebrafish paralogous gene
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.