ArticleNutrition and cancer
Systemic Metabolite Changes in Wild-type C57BL/6 Mice Fed Black Raspberries.
Article in Nutrition and cancer. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- Black raspberry-mediated metabolic changes in patients with familial adenomatous polyposis associated with rectal polyp regression.Food frontiers · 2024Article
- Dysregulated Free Fatty Acid Receptor 2 Exacerbates Colonic Adenoma Formation inJournal of cancer prevention · 2021Article
- Synthesis and Anti-Hepatocarcinoma Effect of Amino Acid Derivatives of Pyxinol and Ocotillol.Molecules (Basel, Switzerland) · 2021Article
- Black raspberries attenuate colonic adenoma development inFood frontiers · 2020Article
- Transplanting fecal material from wild-type mice fed black raspberries alters the immune system of recipient mice.Food frontiers · 2020Article
- Anti-colonic Inflammation by Black Raspberries through Regulating Toll-like Receptor-4 Signaling in Interlukin-10 Knockout Mice.Journal of cancer prevention · 2020Article
- Black raspberries suppress pancreatic cancer through modulation of NKp46Food frontiers · 2020Article
- Impact of dietary gut microbial metabolites on the epigenome.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Colon Cancer: What We Eat.Surgical oncology clinics of North America · 2018Review
- A nutrigenetic approach for investigating the chemopreventive effects of black raspberries during the development of preneoplastic esophagi in rats.Journal of berry research · 2018Article
- Inhibition of the development of N-nitrosomethylbenzylamine-induced esophageal tumors in rats by strawberries and aspirin, alone and in combination.Journal of berry research · 2018Article
- An immunological perspective for preventing cancer with berries.Journal of berry research · 2018Article
- Gut bacteria are required for the benefits of black raspberries inJournal of berry research · 2018Article
- Berries and other natural products in the pancreatic cancer chemoprevention in human clinical trials.Journal of berry research · 2017Article
- Black Raspberries Enhance Natural Killer Cell Infiltration into the Colon and Suppress the Progression of Colorectal Cancer.Frontiers in immunology · 2017Article
- Black Raspberries and Their Anthocyanin and Fiber Fractions Alter the Composition and Diversity of Gut Microbiota in F-344 Rats.Nutrition and cancerArticle
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
introductionFreeze-dried black raspberries (BRBs) elicit chemopreventive effects against colorectal cancer in humans and in rodents. The objective of this study was to investigate potential BRB-caused metabolite changes using wild-type (WT) C57BL/6 mice. METHODS AND
resultsWT mice were fed either control diet or control diet supplemented with 5% BRBs for 8 wk. A nontargeted metabolomic analysis was conducted on colonic mucosa, liver, and fecal specimens collected from both diet groups. BRBs significantly changed the levels of 41 colonic mucosa metabolites, 40 liver metabolites, and 34 fecal metabolites compared to control diet-fed mice. BRBs reduced 34 lipid metabolites in colonic mucosa and increased levels of amino acids in liver. One metabolite, 3-[3-(sulfooxy) phenyl] propanoic acid, might be a useful biomarker of BRB consumption. In addition, BRB powder was found to contain 30-fold higher levels of linolenate compared to control diets. Consistently, multiple omega-3 polyunsaturated fatty acids (ω-3 PUFAs), including stearidonate, docosapentaenoate (ω-3 DPA), eicosapentaenoate (EPA), and docosahexaenoate (DHA), were significantly elevated in livers of BRB-fed mice.
conclusionThe data from the current study suggest that BRBs produce systemic metabolite changes in multiple tissue matrices, supporting our hypothesis that BRBs may serve as both a chemopreventive agent and a beneficial dietary supplement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.