ArticleScientific reports2017
Early-life adversity accelerates cellular ageing and affects adult inflammation: Experimental evidence from the European starling.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- Developmental history, energetic state and choice impulsivity in European starlings, Sturnus vulgaris.Animal cognition · 2019Pooled it
- Genomic Integrity in Gull Chicks Predicts Colony Departure and Postfledging Movements.Ecology and evolution · 2026Article
- Ability to predict irregular periods of food depriviation improves body-weight regulation and reduces weight gain in food-insecure starlings.Royal Society open science · 2025Article
- The balance between care and conflict may be key to understanding maternal aggression in canaries.Scientific reports · 2025Article
- A novel carnivorous diet reduces brain telomere length.Biology letters · 2025Article
- A future food boom rescues the negative effects of early-life adversity on adult lifespan in a small mammal.Proceedings. Biological sciences · 2024Article
- Differential effects of early life adversity on male and female rhesus macaque lifespan.Ecology and evolution · 2023Article
- Natural Animal Populations as Model Systems for Understanding Early Life Adversity Effects on Aging.Integrative and comparative biology · 2023Article
- Causes and consequences of variation in early-life telomere length in a bird metapopulation.Ecology and evolution · 2022Article
- Juvenile confinement exacerbates adversity burden: A neurobiological impetus for decarceration.Frontiers in neuroscience · 2022Article
- Exposure to food insecurity increases energy storage and reduces somatic maintenance in European starlings (Royal Society open science · 2021Article
- Time perception and patience: individual differences in interval timing precision predict choice impulsivity in European starlings, Sturnus vulgaris.Animal cognition · 2021Article
- Early maternal separation is not associated with changes in telomere length in domestic kittens (PeerJ · 2021Article
- Telomere attrition: metabolic regulation and signalling function?Biology letters · 2019Article
- Developmental history and stress responsiveness are related to response inhibition, but not judgement bias, in a cohort of European starlings (Sturnus vulgaris).Animal cognition · 2019Article
- Divergent patterns of telomere shortening in tropical compared to temperate stonechats.Ecology and evolution · 2019Article
- Article
- Bovine telomere dynamics and the association between telomere length and productive lifespan.Scientific reports · 2018Article
- Telomeres as integrative markers of exposure to stress and adversity: a systematic review and meta-analysis.Royal Society open science · 2018Article
- Early-life begging effort reduces adult body mass but strengthens behavioural defence of the rate of energy intake in European starlings.Royal Society open science · 2018Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Early-life adversity is associated with accelerated cellular ageing during development and increased inflammation during adulthood. However, human studies can only establish correlation, not causation, and existing experimental animal approaches alter multiple components of early-life adversity simultaneously. We developed a novel hand-rearing paradigm in European starling nestlings (Sturnus vulgaris), in which we separately manipulated nutritional shortfall and begging effort for a period of 10 days. The experimental treatments accelerated erythrocyte telomere attrition and increased DNA damage measured in the juvenile period. For telomere attrition, amount of food and begging effort exerted additive effects. Only the combination of low food amount and high begging effort increased DNA damage. We then measured two markers of inflammation, high-sensitivity C-reactive protein and interleukin-6, when the birds were adults. The experimental treatments affected both inflammatory markers, though the patterns were complex and different for each marker. The effect of the experimental treatments on adult interleukin-6 was partially mediated by increased juvenile DNA damage. Our results show that both nutritional input and begging effort in the nestling period affect cellular ageing and adult inflammation in the starling. However, the pattern of effects is different for different biomarkers measured at different time points.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.