Evidence map›Paper›PMID 28094030›Full record

ArticleKidney international2017

Glucocorticoid-induced leucine zipper protein regulates sodium and potassium balance in the distal nephron.

Priyanka Rashmi, GianLuca Colussi, Michael Ng, Xinhao Wu, Atif Kidwai, David Pearce

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Observational
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Is There a Role for Genomics in the Management of Hypertension?International journal of molecular sciences · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Priyanka RashmiDivision of Nephrology, Department of Medicine, University of California, San Francisco, California, USA.
GianLuca ColussiDepartment of Experimental and Clinical Medical Sciences, University of Udine, Udine, Italy.
Michael NgDivision of Nephrology, Department of Medicine, University of California, San Francisco, California, USA.
Xinhao WuDivision of Nephrology, Department of Medicine, University of California, San Francisco, California, USA.
Atif KidwaiDivision of Nephrology, Department of Medicine, University of California, San Francisco, California, USA.
David PearceDivision of Nephrology, Department of Medicine, University of California, San Francisco, California, USA. Electronic address: David.Pearce@ucsf.edu.
University of California, San Francisco · USUniversity of Udine · IT

Funding

SGK Regulation of Epithelial Sodium TransportR01DK056695 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DAVID PEARCE · 2000 to 2026
$8.1M
Academic Training Program in NephrologyT32DK007219 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HSU, CHI-YUAN · 1986 to 2022
$7.3M
NIDDK NIH HHS R01 DK056695NIDDK NIH HHS T32 DK007219
6 · The paper itself

Abstract

Glucocorticoid induced leucine zipper protein (GILZ) is an aldosterone-regulated protein that controls sodium transport in cultured kidney epithelial cells. Mice lacking GILZ have been reported previously to have electrolyte abnormalities. However, the mechanistic basis has not been explored. Here we provide evidence supporting a role for GILZ in modulating the balance of renal sodium and potassium excretion by regulating the sodium-chloride cotransporter (NCC) activity in the distal nephron. Gilz

Indexed as

AnimalsHEK293 CellsHumansHyperkalemiaHypertensionMaleMiceMice, KnockoutMinor Histocompatibility AntigensNephronsPhosphorylationPotassiumProtein Serine-Threonine KinasesPseudohypoaldosteronismReninSignal TransductionDsip1 protein, mouseMinor Histocompatibility AntigensPotassiumPrkwnk4 protein, mouseProtein Serine-Threonine KinasesReninSodiumSodium Chloride SymportersSolute Carrier Family 12, Member 3STK39 protein, humanStk39 protein, mouseThiazidesTranscription FactorsWnk1 protein, mouseWNK Lysine-Deficient Protein Kinase 1aldosteronedistal tubulehypernatremiapotassium channels

Identifiers

PMID28094030
PMCPMC6034684
OpenAlexW2579493677

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.