ArticleRenal failure2017
Acute kidney injury in idiopathic nephrotic syndrome of childhood is a major risk factor for the development of chronic kidney disease.
Article in Renal failure, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Association between MCP-1 2518 A>G gene polymorphism and chronic kidney disease.International urology and nephrology · 2018Pooled it
- Lung ultrasonography for assessment of fluid overload in children with acute kidney injury undergoing hemodialysis: a prospective pilot study.Pediatric nephrology (Berlin, Germany) · 2026Observational
- Development and external validation of a machine learning-based predictive model for acute kidney injury in hospitalized children with idiopathic nephrotic syndrome.BMC medical informatics and decision making · 2025Article
- Article
- Risk factors and renal outcomes of AKI in children with secondary steroid-resistant nephrotic syndrome.Renal failure · 2024Article
- Adult survivors of childhood-onset steroid-dependent and steroid-resistant nephrotic syndrome treated with cyclosporine: a long-term single-center experience.Pediatric nephrology (Berlin, Germany) · 2024Article
- Clinical Profile and Outcomes of Nephrotic Syndrome With Acute Kidney Injury in Adults: A Prospective Cohort Study.Cureus · 2023Article
- Serum free fatty acid elevation is related to acute kidney injury in primary nephrotic syndrome.Renal failure · 2022Article
- Disease-Associated Systemic Complications in Childhood Nephrotic Syndrome: A Systematic Review.International journal of nephrology and renovascular disease · 2022Article
- Factors predicting the recovery from acute kidney injury in children with primary nephrotic syndrome.Clinical and experimental nephrology · 2021Article
- Lower albumin level and longer disease duration are risk factors of acute kidney injury in hospitalized children with nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2021Article
- Timing and predictive factors of developing chronic kidney disease in childhood-onset idiopathic nephrotic syndrome: an Asian experience.Singapore medical journal · 2020Article
- Nephrotic syndrome-associated hypercoagulopathy is alleviated by both pioglitazone and glucocorticoid which target two different nuclear receptors.Physiological reports · 2020Article
- Infections and risk of end-stage renal disease in patients with nephrotic syndrome: a nationwide population-based case-control study.Annals of translational medicine · 2020Article
- Impact of acute kidney injury at the onset of idiopathic nephrotic syndrome in Japanese children.Clinical and experimental nephrology · 2019Article
- Pathogenesis and Management of Acute Kidney Injury in Patients with Nephrotic Syndrome Due to Primary Glomerulopathies.Medicina (Kaunas, Lithuania) · 2019Review
- Acute kidney injury in childhood-onset nephrotic syndrome: Incidence and risk factors in hospitalized patients.Kidney research and clinical practice · 2018Article
- Acute Kidney Injury in Nephrotic Syndrome.Frontiers in pediatrics · 2018Review
- Monitoring and manipulating cellular crosstalk during kidney fibrosis inside a 3D in vitro co-culture.Scientific reports · 2017Article
- [Early identification of acute kidney injury in children with primary nephrotic syndrome].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatricsArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute kidney injury (AKI) is an important complication of idiopathic nephrotic syndrome (INS) and is associated with adverse outcomes, especially the development of chronic kidney disease (CKD). We aimed to determine the clinical profile of children with INS who developed AKI and its short-term outcome. MATERIAL AND
methodsThis prospective study was conducted from March 2014 to October 2015. A total of 119 children of INS (age: 2-18 years) fulfilling the pediatric RIFLE criteria for the diagnosis of AKI were enrolled and followed up for 3 months to determine the outcome. Factors predisposing to CKD were studied.
resultsThe mean age at presentation was 8.8 ± 3.59 years and males were 74 (62.2%). At presentation, 61 (51.3%) children were in Risk category, 43 (36.1%) in Injury category, and 15 (12.6%) in Failure category. Most of them (41.2%) had steroid-resistant nephrotic syndrome (SRNS) and focal segmental glomerulosclerosis (FSGS) on histopathology (33.6%). Infections were the major predisposing factor for AKI in 67 (56.3%) cases. Drug toxicity was the next common, found in 52 (43.7%) children. A total of 65 (54.6%) children recovered from AKI, while 54 (45.4%) did not. CKD developed in 49 (41.2%) non-recovered cases and 5 (4.2%) children succumbed to acute illness. SRNS, cyclosporine use, FSGS on histology, and drug toxicity were significant factors associated with the development of CKD.
conclusionAKI associated with INS is a reversible condition in most cases but it can progress to CKD, especially among those who have SRNS, FSGS, and drug toxicity.
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