ArticleActa orthopaedica2017
Toll-like receptors and their soluble forms differ in the knee and thumb basal osteoarthritic joints.
Article in Acta orthopaedica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 32 citations in OpenAlex.
- Biomarkers of inflammation - LBP and TLR- predict progression of knee osteoarthritis in the DOXY clinical trial.Osteoarthritis and cartilage · 2018Trial
- Circulating sTLR4 and sTREM-1 in Knee Osteoarthritis: Associations with Study-Specific MRI-Defined Categories and Disease Burden.Journal of clinical medicine · 2026Article
- Research progress on the role of CD14 in osteoarthritis.Frontiers in immunology · 2026Review
- Article
- Joint Tissues: Convergence and Divergence of the Pathogenetic Mechanisms of Rheumatoid Arthritis and Osteoarthritis.International journal of molecular sciences · 2025Review
- Evaluating the role of lipopolysaccharides in the joint: fibronectin as a novel protective mechanism.RMD open · 2025Article
- The TLR-M-CSF axis is implicated in increased bone turnover and curve progression in adolescent idiopathic scoliosis.Arthritis research & therapy · 2025Article
- NOS inhibition reverses TLR2-induced chondrocyte dysfunction and attenuates age-related osteoarthritis.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Phenotype Diversity of Macrophages in Osteoarthritis: Implications for Development of Macrophage Modulating Therapies.International journal of molecular sciences · 2022Review
- Toll-like receptor 3 activation promotes joint degeneration in osteoarthritis.Cell death & disease · 2022Article
- Osteoarthritis Data Integration Portal (OsteoDIP): A web-based gene and non-coding RNA expression database.Osteoarthritis and cartilage open · 2022Article
- Effect of cell receptors in the pathogenesis of osteoarthritis: Current insights.Open life sciences · 2022Review
- Innate Immunity at the Core of Sex Differences in Osteoarthritic Pain?Frontiers in pharmacology · 2022Review
- Celastrol ameliorates osteoarthritisFrontiers in pharmacology · 2022Article
- Article
- The Expression of Inflammasomes NLRP1 and NLRP3, Toll-Like Receptors, and Vitamin D Receptor in Synovial Fibroblasts From Patients With Different Types of Knee Arthritis.Frontiers in immunology · 2021Article
- Anti-Inflammatory and Chondroprotective Effects of Vanillic Acid and Epimedin C in Human Osteoarthritic Chondrocytes.Biomolecules · 2020Article
- Osteoarthritis and Toll-Like Receptors: When Innate Immunity Meets Chondrocyte Apoptosis.Biology · 2020Review
- The Damage-Associated Molecular Patterns (DAMPs) as Potential Targets to Treat Osteoarthritis: Perspectives From a Review of the Literature.Frontiers in medicine · 2020Review
- Serum soluble toll-like receptor 2 and 4 as diagnostic and prognostic biomarkers for non-Hodgkin lymphoma.Contemporary oncology (Poznan, Poland) · 2020Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and purpose - Although the pathogenesis of osteoarthritis (OA) is not well understood, chondrocyte-mediated inflammatory responses (triggered by the activation of innate immune receptors by damage-associated molecules) are thought to be involved. We examined the relationship between Toll-like receptors (TLRs) and OA in cartilage from 2 joints differing in size and mechanical loading: the first carpometacarpal (CMC-I) and the knee. Patients and methods - Samples of human cartilage obtained from OA CMC-I and knee joints were immunostained for TLRs (1-9) and analyzed using histomorphometry and principal component analysis (PCA). mRNA expression levels were analyzed with RT-PCR. Collected synovial fluid (SF) samples were screened for the presence of soluble forms of TLR2 and TLR4 by enzyme-linked immunosorbent assay (ELISA). Results - In contrast to knee OA, TLR expression in CMC-I OA did not show grade-dependent overall profile changes, but PCA revealed that TLR expression profiles clustered according to their cellular compartment organization. Protein levels of TLR4 were substantially higher in knee OA than in CMC-I OA, while the opposite was the case at the mRNA level. ELISA assays confirmed the presence of soluble forms of TLR2 and TLR4 in SF, with sTLR4 being considerably higher in CMC-I OA than in knee OA. Interpretation - We observed that TLRs are differentially expressed in OA cartilage, depending on the joint. Soluble forms of TLR2 and TLR4 were detected for the first time in SF of osteoarthritic joints, with soluble TLR4 being differentially expressed. Together, our results suggest that negative regulatory mechanisms of innate immunity may be involved in the pathomolecular mechanisms of osteoarthritis.
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