ArticleMolecular plant pathology2018
Fusaric acid contributes to virulence of Fusarium oxysporum on plant and mammalian hosts.
Article in Molecular plant pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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Who cites it
77 citing papers in PubMed, 150 citations in OpenAlex.
- Pathogenicity and Virulence ofVirulence · 2026Review
- Virulence determinants of Fusarium oxysporum for clinical infections.PLoS pathogens · 2026Article
- Inhibitory Effects and Mechanisms of Thymol AgainstMetabolites · 2026Article
- Multifunctional biological roles of Fusaric acid and its derivatives in the Diverse Kingdoms of Life: Insights from More Than Nine Decades of Research.Pharmaceutical research · 2026Review
- Ratiometric Mycotoxin Detection in Living Plants With Dual-Emissive Nanosensors.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Genome reshaping by Helitron transposons in Fusarium oxysporum TR4 affects secondary metabolism but not virulence.Nature communications · 2026Article
- Comparative genomics of Fusarium oxysporum f. sp. albedinis reveals the effector repertoire and molecular arsenal for date palm infection.BMC plant biology · 2026Article
- Article
- Mating-Type Loci Modulate Pathogenicity and Non-Sexual Development Through Autocrine Pheromone Signalling in the Asexual Fungus Fusarium oxysporum.Molecular plant pathology · 2026Article
- Histidinol-Phosphate Phosphatase FoHis2 Is Essential for Growth, Stress Responses, and Full Virulence inJournal of fungi (Basel, Switzerland) · 2026Article
- Molecular Strategies and Regulatory Networks in the Early Infection Stages of Plant Pathogenic Fusarium Species.The plant pathology journal · 2026Review
- Synthetic microbial communities for plant growth promotion and soil-borne disease suppression: design principles, mechanisms, and translational challenges.Frontiers in microbiology · 2026Review
- The impact of environmental variations (temperature and humidity) onFrontiers in fungal biology · 2026Article
- Article
- Phenolic Compounds Accumulation and Cell Death Degree Induced by Fusaric Acid in Agroforestry Hosts Plants ofJournal of fungi (Basel, Switzerland) · 2025Article
- Genetic and molecular approaches for Fusarium wilt resistance in garden pea: advances and future outlook.Plant molecular biology · 2025Review
- Environmental Xenobiotics and Epigenetic Modifications: Implications for Human Health and Disease.Journal of xenobiotics · 2025Review
- Bacterial extracellular biomolecules-derived multimodal manganese nanoparticles control watermelon Fusarium wilt by dysregulating fusaric acid biosynthesis pathway and precise tuning of rhizosphere metabolome.Journal of nanobiotechnology · 2025Article
- Fusaric acid-mediated S-glutathionylation of MaAKT1 channel confers the virulence of Foc TR4 to banana.PLoS pathogens · 2025Article
- Fungal Metabolomics: A Comprehensive Approach to Understanding Pathogenesis in Humans and Identifying Potential Therapeutics.Journal of fungi (Basel, Switzerland) · 2025Review
17 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fusaric acid (FA) is amongst the oldest identified secondary metabolites produced by Fusarium species, known for a long time to display strong phytotoxicity and moderate toxicity to animal cells; however, the cellular targets of FA and its function in fungal pathogenicity remain unknown. Here, we investigated the role of FA in Fusarium oxysporum, a soil-borne cross-kingdom pathogen that causes vascular wilt on more than 100 plant species and opportunistic infections in humans. Targeted deletion of fub1, encoding a predicted orthologue of the polyketide synthase involved in FA biosynthesis in F. verticillioides and F. fujikuroi, abolished the production of FA and its derivatives in F. oxysporum. We further showed that the expression of fub1 was positively controlled by the master regulator of secondary metabolism LaeA and the alkaline pH regulator PacC through the modulation of chromatin accessibility at the fub1 locus. FA exhibited strong phytotoxicity on tomato plants, which was rescued by the exogenous supply of copper, iron or zinc, suggesting a possible function of FA as a chelating agent of these metal ions. Importantly, the severity of vascular wilt symptoms on tomato plants and the mortality of immunosuppressed mice were significantly reduced in fub1Δ mutants and fully restored in the complemented strains. Collectively, these results provide new insights into the regulation and mode of action of FA, as well as on the function of this phytotoxin during the infection process of F. oxysporum.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.