Evidence map›Paper›PMID 28093576›Full record

ArticleMedChemComm2016

Synthetic α-Hydroxytropolones as Inhibitors of HIV Reverse Transcriptase Ribonuclease H Activity.

Ryan P Murelli, Michael P D'Erasmo, Danielle R Hirsch, Christine Meck, Takashi Masaoka, Jennifer A Wilson, Baofeng Zhang, Rajat K Pal, Emilio Gallicchio, John A Beutler and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedChemComm, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Effects of Troponoids on Mitochondrial Function and Cytotoxicity.Antimicrobial agents and chemotherapy · 2022
    Article
  4. Review
  5. Article
  6. Article
  7. Fluorous-Phase Approach to α-Hydroxytropolone Synthesis.The Journal of organic chemistry · 2018
    Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Ryan P MurelliDepartment of Chemistry, Brooklyn College, The City University of New York, Brooklyn, New York, USA; PhD Program in Chemistry, The Graduate Center of The City University of New York, New York, NY, USA.
Michael P D'ErasmoDepartment of Chemistry, Brooklyn College, The City University of New York, Brooklyn, New York, USA; PhD Program in Chemistry, The Graduate Center of The City University of New York, New York, NY, USA.
Danielle R HirschDepartment of Chemistry, Brooklyn College, The City University of New York, Brooklyn, New York, USA; PhD Program in Chemistry, The Graduate Center of The City University of New York, New York, NY, USA.
Christine MeckDepartment of Chemistry, Brooklyn College, The City University of New York, Brooklyn, New York, USA; PhD Program in Chemistry, The Graduate Center of The City University of New York, New York, NY, USA.
Takashi MasaokaBasic Research Laboratory, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD, USA.
Jennifer A WilsonMolecular Targets Laboratory, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD, USA.
Baofeng ZhangDepartment of Chemistry, Brooklyn College, The City University of New York, Brooklyn, New York, USA.
Rajat K PalDepartment of Chemistry, Brooklyn College, The City University of New York, Brooklyn, New York, USA; PhD Program in Biochemistry, The Graduate Center of The City University of New York, New York, NY, USA.
Emilio GallicchioDepartment of Chemistry, Brooklyn College, The City University of New York, Brooklyn, New York, USA; PhD Program in Chemistry, The Graduate Center of The City University of New York, New York, NY, USA; PhD Program in Biochemistry, The Graduate Center of The City University of New York, New York, NY, USA.
John A BeutlerMolecular Targets Laboratory, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD, USA.
Stuart F J Le GriceBasic Research Laboratory, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD, USA.
City University of New York · USBrooklyn College · USNational Cancer Institute · USThe Graduate Center, CUNY · USFrederick Community College · USTarget (United States) · US

Funding

Development and Exploitation of New Synthetic Strategies for TropolonesSC1GM111158 · NIGMS · BROOKLYN COLLEGE · PI MURELLI, RYAN · 2015 to 2023
$3.1M
NIGMS NIH HHS SC1 GM111158
6 · The paper itself

Abstract

HIV Reverse Transcriptase-associated ribonuclease H activity is a promising enzymatic target for drug development that has not been successfully targeted in the clinic. While the α-hydroxytropolone-containing natural products β-thujaplicinol and manicol have emerged as some of the most potent leads described to date, structure-function studies have been limited to the natural products and semi-synthetic derivatives of manicol. Thus, a library of α-hydroxytropolones synthesized through a convenient oxidopyrylium cycloaddition/ring-opening sequence have been tested in

Identifiers

PMID28093576
PMCPMC5234084
OpenAlexW2463495507

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.