Evidence map›Paper›PMID 28093568›Full record

SynthesisMolecular psychiatry2017

GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium.

J W Trampush, M L Z Yang, J Yu, E Knowles, G Davies, D C Liewald, J M Starr, S Djurovic, I Melle, K Sundet and 56 more

Erratum issuedOpen access · hybridAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Molecular psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 129 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed, 13 pooled it
30.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

129 citing papers in PubMed, 13 syntheses or guidelines pooled it, 301 citations in OpenAlex.

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69 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

66 authors at 20 institutions in 9 countries.

J W TrampushDivision of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, NY, USA.
M L Z YangInstitute of Mental Health, Singapore, Singapore.
J YuDivision of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, NY, USA.
E KnowlesDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
G DaviesCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
D C LiewaldDepartment of Psychology, University of Edinburgh, Edinburgh, UK.
J M StarrCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
S DjurovicDepartment of Medical Genetics, Oslo University Hospital, University of Bergen, Oslo, Norway.
I MelleNORMENT, K.G. Jebsen Centre for Psychosis Research, University of Bergen, Bergen, Norway.
K SundetDivision of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
A ChristoforouNORMENT, K.G. Jebsen Centre for Psychosis Research, University of Bergen, Bergen, Norway.
I ReinvangDepartment of Psychology, University of Oslo, Oslo, Norway.
P DeRosseDivision of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, NY, USA.
A J LundervoldDepartment of Biological and Medical Psychology, University of Bergen, Bergen, Norway.
V M SteenNORMENT, K.G. Jebsen Centre for Psychosis Research, University of Bergen, Bergen, Norway.
T EspesethDivision of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
K RäikkönenInstitute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.
E WidenInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
A PalotieInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
J G ErikssonNational Institute for Health and Welfare, Helsinki, Finland.
I GieglingDepartment of Psychiatry, Martin Luther University of Halle-Wittenberg, Halle, Germany.
B KonteDepartment of Psychiatry, Martin Luther University of Halle-Wittenberg, Halle, Germany.
P RoussosDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
S GiakoumakiDepartment of Psychology, University of Crete, Rethymno, Greece.
K E BurdickDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
A PaytonManchester Centre for Audiology and Deafness, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.
W OllierCentre for Integrated Genomic Medical Research, Institute of Population Health, University of Manchester, Manchester, UK.
M HoranManchester Medical School, Institute of Brain, Behaviour, and Mental Health, University of Manchester, Manchester, UK.
O Chiba-FalekDepartment of Neurology, Bryan Alzheimer's Disease Research Center, and Center for Genomic and Computational Biology, Duke University Medical Center, Durham, NC, USA.
D K AttixDepartment of Neurology, Bryan Alzheimer's Disease Research Center, and Center for Genomic and Computational Biology, Duke University Medical Center, Durham, NC, USA.
A C NeedDivision of Brain Sciences, Department of Medicine, Imperial College, London, UK.
E T CirulliCenter for Applied Genomics and Precision Medicine, Duke University School of Medicine, Durham, NC, USA.
A N VoineskosCampbell Family Mental Health Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada.
N C StefanisDepartment of Psychiatry, University of Athens School of Medicine, Eginition Hospital, Athens, Greece.
D AvramopoulosDepartment of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
A HatzimanolisDepartment of Psychiatry, University of Athens School of Medicine, Eginition Hospital, Athens, Greece.
D E ArkingDepartment of Psychiatry and McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
N SmyrnisDepartment of Psychiatry, University of Athens School of Medicine, Eginition Hospital, Athens, Greece.
R M BilderUCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA.
N A FreimerUCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA.
T D CannonDepartment of Psychology, Yale University, New Haven, CT, USA.
E LondonUCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA.
R A PoldrackDepartment of Psychology, Stanford University, Palo Alto, CA, USA.
F W SabbRobert and Beverly Lewis Center for Neuroimaging, University of Oregon, Eugene, OR, USA.
E CongdonUCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA.
E D Conley23andMe, Inc., Mountain View, CA, USA.
M A ScultDepartment of Psychology & Neuroscience, Laboratory of NeuroGenetics, Duke University, Durham, NC, USA.
D DickinsonClinical and Translational Neuroscience Branch, Intramural Research Program, National Institute of Mental Health, National Institute of Health, Bethesda, MD, USA.
R E StraubLieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore, MD, USA.
G DonohoeDepartment of Psychology, National University of Ireland, Galway, Ireland.
D MorrisDepartment of Psychiatry, Neuropsychiatric Genetics Research Group, Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
A CorvinDepartment of Psychiatry, Neuropsychiatric Genetics Research Group, Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
M GillDepartment of Psychiatry, Neuropsychiatric Genetics Research Group, Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
A R HaririDepartment of Psychology & Neuroscience, Laboratory of NeuroGenetics, Duke University, Durham, NC, USA.
D R WeinbergerLieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore, MD, USA.
N PendletonCentre for Integrated Genomic Medical Research, Institute of Population Health, University of Manchester, Manchester, UK.
P BitsiosDepartment of Psychiatry and Behavioral Sciences, Faculty of Medicine, University of Crete, Heraklion, Greece.
D RujescuDepartment of Psychiatry, Martin Luther University of Halle-Wittenberg, Halle, Germany.
J LahtiInstitute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.
S Le HellardNORMENT, K.G. Jebsen Centre for Psychosis Research, University of Bergen, Bergen, Norway.
M C KellerInstitute for Behavioral Genetics, University of Colorado, Boulder, CO, USA.
O A AndreassenNORMENT, K.G. Jebsen Centre for Psychosis Research, University of Bergen, Bergen, Norway.
I J DearyCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
D C GlahnDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
A K MalhotraDivision of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, NY, USA.
T LenczDivision of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, NY, USA.
Duke University · USUniversity of Helsinki · FIUniversity of Bergen · NOZucker Hillside Hospital · USJohns Hopkins University · USMartin Luther University Halle-Wittenberg · DETrinity College Dublin · IEUniversity of Edinburgh · GBUniversity of Manchester · GBUniversity of Oslo · NOYale University · USHaukeland University Hospital · NOUniversity Mental Health Research Institute · GRUniversity of Crete · GR23andMe (United States) · USAlzheimer Scotland · GBEginition Hospital · GRHofstra University · USIcahn School of Medicine at Mount Sinai · USImperial College London · GB

Funding

THE FRAMINGHAM HEART STUDYN01HC25195 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN S · 2007 to 2014
$83.8M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Neuroimaging of Brain Circuits and Neurogenetic Mechanisms in Normal CognitionZIAMH002717 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI BERMAN, KAREN FAITH · 2009 to 2024
$21.8M
CANDIDATE GENE ASSOCIATION RESOURCE (CARE)N01HC65226 · NHLBI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY · 2007 to 2009
$17.0M
UCLA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR033176 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2011 to 2011
$15.5M
Neurodevelopmental Genomics: Trajectories of Complex PhenotypesRC2MH089983 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GUR, RAQUEL E · 2009 to 2011
$14.3M
Substance Abuse & Behavioral Disinhibition: Integrating Genes & EnvironmentU01DA024417 · NIDA · UNIVERSITY OF MINNESOTA · PI IACONO, WILLIAM G. · 2007 to 2010
$10.8M
2/2 Neurodevelopmental Genomics: Trajectories of Complex PhenotypesRC2MH089924 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI HAKONARSON, HAKON · 2009 to 2011
$10.7M
Quantifying Individual Differences in Midlife Structural Brain Integrity Associated with Later AD/ADRD RiskR01AG049789 · NIA · DUKE UNIVERSITY · PI AHMAD R. HARIRI, TERRIE E MOFFITT · 2015 to 2026
$10.6M
Striatal D2/D3 Dopamine receptor availability in first episode schizophreniaP50MH080173 · NIMH · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI GREGERSEN, PETER K. · 2008 to 2012
$10.4M
Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5M
SNP HEALTH ASSOCIATION RESOURCE (SHARE)N02HL64278 · NHLBI · PI CHIN, SIANG · 2007 to 2007
$9.2M
Biotechnology and Biological Sciences Research Council BB/F019394/1Biotechnology and Biological Sciences Research Council BB/F022441/1Medical Research Council MC_QA137853Medical Research Council MR/K026992/1NCATS NIH HHS UL1 TR000124NCRR NIH HHS UL1 RR033176NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS N01HC25195NHLBI NIH HHS N01HC55222NHLBI NIH HHS N01HC65226NHLBI NIH HHS N01HC75150NHLBI NIH HHS N01HC85079NHLBI NIH HHS N01HC85080NHLBI NIH HHS N01HC85081NHLBI NIH HHS N01HC85082NHLBI NIH HHS N01HC85083NHLBI NIH HHS N01HC85086NHLBI NIH HHS N02HL64278NHLBI NIH HHS U01 HL080295NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG049789NIDA NIH HHS R01 DA033369NIDA NIH HHS RL1 DA024853NIDA NIH HHS U01 DA024417NIDCR NIH HHS UL1 DE019580NIMH NIH HHS K01 MH085812NIMH NIH HHS K01 MH098126NIMH NIH HHS K23 MH077807NIMH NIH HHS P50 MH080173NIMH NIH HHS PL1 MH083271NIMH NIH HHS R01 MH079800NIMH NIH HHS R01 MH080912NIMH NIH HHS R01 MH085018NIMH NIH HHS R01 MH092515NIMH NIH HHS R01 MH100141NIMH NIH HHS RC2 MH089924NIMH NIH HHS RC2 MH089983NIMH NIH HHS RL1 MH083269NINDS NIH HHS PL1 NS062410
6 · The paper itself

Abstract

The complex nature of human cognition has resulted in cognitive genomics lagging behind many other fields in terms of gene discovery using genome-wide association study (GWAS) methods. In an attempt to overcome these barriers, the current study utilized GWAS meta-analysis to examine the association of common genetic variation (~8M single-nucleotide polymorphisms (SNP) with minor allele frequency ⩾1%) to general cognitive function in a sample of 35 298 healthy individuals of European ancestry across 24 cohorts in the Cognitive Genomics Consortium (COGENT). In addition, we utilized individual SNP lookups and polygenic score analyses to identify genetic overlap with other relevant neurobehavioral phenotypes. Our primary GWAS meta-analysis identified two novel SNP loci (top SNPs: rs76114856 in the CENPO gene on chromosome 2 and rs6669072 near LOC105378853 on chromosome 1) associated with cognitive performance at the genome-wide significance level (P<5 × 10

Indexed as

AdultAllelesCognitionFemaleGene FrequencyGenetic Association StudiesGenetic LociGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyHumansMaleMiddle AgedMultifactorial InheritanceNeurocognitive DisordersPolymorphism, Single Nucleotide

Identifiers

PMID28093568
PMCPMC5322272
OpenAlexW2575342665

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.