Evidence map›Paper›PMID 28093560›Full record

ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2017

Integrating Hebbian and homeostatic plasticity: introduction.

Kevin Fox, Michael Stryker

Registry-linked trialAbstract read
In one paragraph

Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04441515 (Music After Stroke To Enhance Rehabilitation), which is not on this map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04441515 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Music After Stroke To Enhance Rehabilitation

TypeinterventionalSponsorPace UniversityRan2021 to 2023Enrolled12ConditionsStroke, Acute, Expressive Aphasia, Movement, Abnormal, Depressive DisorderArmsIpod with music, ipod with books to listen, ipod only with usual care
3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

  1. Brain organization of a memory champion.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Rapid rebalancing of co-tuned ensemble activity in the auditory cortex.bioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. eLife · 2024
    Article
  13. Article
  14. Review
  15. Disuse-driven plasticity in the human thalamus and putamen.bioRxiv : the preprint server for biology · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Neural Plasticity in Sensorimotor Brain-Machine Interfaces.Annual review of biomedical engineering · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kevin FoxSchool of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK Foxkd@cardiff.ac.uk.ORCID 0000-0002-2563-112X
Michael StrykerCenter for Integrative Neuroscience, University of California, 675 Nelson Rising Lane, San Francisco, CA 94158, USA.ORCID 0000-0003-1546-5831

Funding

DEVELOPMENT &PLASTICITY OF THE VISUAL SYSTEMR01EY002874 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STRYKER, MICHAEL P · 1986 to 2022
$6.4M
Interneuron Precursors and the induction of cortical plasticityR01EY025174 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ALVAREZ-BUYLLA, ARTURO, HASENSTAUB, ANDREA RAYNE · 2015 to 2019
$2.1M
NEI NIH HHS R01 EY002874NEI NIH HHS R01 EY025174
6 · The paper itself

Abstract

Hebbian plasticity is widely considered to be the mechanism by which information can be coded and retained in neurons in the brain. Homeostatic plasticity moves the neuron back towards its original state following a perturbation, including perturbations produced by Hebbian plasticity. How then does homeostatic plasticity avoid erasing the Hebbian coded information? To understand how plasticity works in the brain, and therefore to understand learning, memory, sensory adaptation, development and recovery from injury, requires development of a theory of plasticity that integrates both forms of plasticity into a whole. In April 2016, a group of computational and experimental neuroscientists met in London at a discussion meeting hosted by the Royal Society to identify the critical questions in the field and to frame the research agenda for the next steps. Here, we provide a brief introduction to the papers arising from the meeting and highlight some of the themes to have emerged from the discussions.This article is part of the themed issue 'Integrating Hebbian and homeostatic plasticity'.

Indexed as

Feedback, SensoryHomeostasisNeuronal PlasticityAnimalsBrainHumansLearningMammalsMemoryNeuronscortical plasticitydisinhibitionLTDLTPnegative feedbacksynaptic scaling

Identifiers

PMID28093560
PMCPMC5247598

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.