ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2017
Variance and invariance of neuronal long-term representations.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed.
- Bypass neural interfaces for paralysis: clinical translation, challenges and future directions.Journal of neuroengineering and rehabilitation · 2026Review
- Voltage imaging of CA1 pyramidal cells and SST+ interneurons reveals stability and plasticity mechanisms of spatial firing.Nature communications · 2026Article
- Representational drift gates critical-period plasticity in mouse visual cortex.Current biology : CB · 2025Article
- Maintenance of memory by negative-feedback of synaptic protein elimination: Modeling KIBRA-bioRxiv : the preprint server for biology · 2025Article
- Article
- Multi-day neuron tracking in high-density electrophysiology recordings using earth mover's distance.eLife · 2024Article
- Article
- Multi-day Neuron Tracking in High Density Electrophysiology Recordings using EMD.bioRxiv : the preprint server for biology · 2024Article
- Induction of excitatory brain state governs plastic functional changes in visual cortical topology.Brain structure & function · 2024Review
- Decoding motor plans using a closed-loop ultrasonic brain-machine interface.Nature neuroscience · 2024Article
- Reconstructing computational system dynamics from neural data with recurrent neural networks.Nature reviews. Neuroscience · 2023Review
- Representational drift in barrel cortex is receptive field dependent.bioRxiv : the preprint server for biology · 2023Article
- Sparse and distributed cortical populations mediate sensorimotor integration.bioRxiv : the preprint server for biology · 2023Article
- Flexible regulation of representations on a drifting manifold enables long-term stable complex neuroprosthetic control.bioRxiv : the preprint server for biology · 2023Article
- Learning in a sensory cortical microstimulation task is associated with elevated representational stability.Nature communications · 2023Article
- Principles of nociceptive coding in the anterior cingulate cortex.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Pain-induced adaptations in the claustro-cingulate pathway.Cell reports · 2023Article
- To be and not to be: wide-field Ca2+ imaging reveals neocortical functional segmentation combines stability and flexibility.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- A stable sensory map emerges from a dynamic equilibrium of neurons with unstable tuning properties.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Stability and flexibility of odor representations in the mouse olfactory bulb.Frontiers in neural circuits · 2023Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The brain extracts behaviourally relevant sensory input to produce appropriate motor output. On the one hand, our constantly changing environment requires this transformation to be plastic. On the other hand, plasticity is thought to be balanced by mechanisms ensuring constancy of neuronal representations in order to achieve stable behavioural performance. Yet, prominent changes in synaptic strength and connectivity also occur during normal sensory experience, indicating a certain degree of constitutive plasticity. This raises the question of how stable neuronal representations are on the population level and also on the single neuron level. Here, we review recent data from longitudinal electrophysiological and optical recordings of single-cell activity that assess the long-term stability of neuronal stimulus selectivities under conditions of constant sensory experience, during learning, and after reversible modification of sensory input. The emerging picture is that neuronal representations are stabilized by behavioural relevance and that the degree of long-term tuning stability and perturbation resistance directly relates to the functional role of the respective neurons, cell types and circuits. Using a 'toy' model, we show that stable baseline representations and precise recovery from perturbations in visual cortex could arise from a 'backbone' of strong recurrent connectivity between similarly tuned cells together with a small number of 'anchor' neurons exempt from plastic changes.This article is part of the themed issue 'Integrating Hebbian and homeostatic plasticity'.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.