ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2017
Tumour necrosis factor-mediated homeostatic synaptic plasticity in behavioural models: testing a role in maternal immune activation.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Decreased hippocampal neurite density in late-middle-aged adults following prenatal exposure to higher levels of maternal inflammation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Decreased hippocampal neurite density in late middle-aged adults following prenatal exposure to higher levels of maternal inflammation.bioRxiv : the preprint server for biology · 2025Article
- GABA system as the cause and effect in early development.Neuroscience and biobehavioral reviews · 2024Review
- Complex Neuroimmune Involvement in Neurodevelopment: A Mini-Review.Journal of inflammation research · 2023Review
- Neurocognitive outcomes in Malawian children exposed to malaria during pregnancy: An observational birth cohort study.PLoS medicine · 2021Observational
- In utero immune programming of autism spectrum disorder (ASD).Human immunology · 2021Article
- The Role of Neuroinflammation in Post-traumatic Epilepsy.Frontiers in neurology · 2021Review
- Tumour Necrosis Factor in Neuroplasticity, Neurogenesis and Alcohol Use Disorder.Brain plasticity (Amsterdam, Netherlands) · 2020Review
- Enduring neuroimmunological consequences of developmental experiences: From vulnerability to resilience.Molecular and cellular neurosciences · 2020Review
- Brain changes in a maternal immune activation model of neurodevelopmental brain disorders.Progress in neurobiology · 2019Review
- Tumor Necrosis Factor-Alpha Alters Electrophysiological Properties of Rabbit Hippocampal Neurons.Journal of Alzheimer's disease : JAD · 2019Article
- Variability in PolyIC induced immune response: Implications for preclinical maternal immune activation models.Journal of neuroimmunology · 2018Article
- Depression following a traumatic brain injury: uncovering cytokine dysregulation as a pathogenic mechanism.Neural regeneration research · 2018Review
- Integrating Hebbian and homeostatic plasticity: introduction.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- Neuroinflammation, Early-Life Adversity, and Brain Development.Harvard review of psychiatryReview
- Neuroimmunological effects of early life experiences.Brain and neuroscience advancesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
The proinflammatory cytokine tumour necrosis factor-alpha (TNFα) has long been characterized for its role in the innate immune system, but more recently has been found to have a distinct role in the nervous system that does not overlap with other proinflammatory cytokines. Through regulation of neuronal glutamate and GABA receptor trafficking, TNF mediates a homeostatic form of synaptic plasticity, but plays no direct role in Hebbian forms of plasticity. As yet, there is no evidence to suggest that this adaptive plasticity plays a significant role in normal development, but it does maintain neuronal circuit function in the face of several types of disruption. This includes developmental plasticity in primary sensory cortices, as well as modulating the response to antidepressants, chronic antipsychotics and drugs of abuse. TNF is also a prominent component of the neuroinflammation occurring in most neuropathologies, but the role of TNF-mediated synaptic plasticity in this context remains to be determined. We tested this in a maternal immune activation (MIA) model of neurodevelopmental disorders. Using TNF
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.