ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2017
Experience-dependent homeostasis of 'noise' at inhibitory synapses preserves information coding in adult visual cortex.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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20 citing papers in PubMed, 28 citations in OpenAlex.
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- Tuning excitatory input to fast-spiking parvalbumin-positive interneurons: a lever for plasticity and hyperexcitability across the lifespan.Frontiers in synaptic neuroscience · 2026Article
- Phosphorylation of GABAScientific reports · 2025Article
- Visual Cortical Plasticity: Molecular Mechanisms as Revealed by Induction Paradigms in Rodents.International journal of molecular sciences · 2023Review
- Circadian time- and sleep-dependent modulation of cortical parvalbumin-positive inhibitory neurons.The EMBO journal · 2023Article
- Sex and estrous cycle affect experience-dependent plasticity in mouse primary visual cortex.PloS one · 2023Article
- Electrophysiological properties of layer 2/3 pyramidal neurons in the primary visual cortex of a retinitis pigmentosa mouse model (Frontiers in cellular neuroscience · 2023Article
- Developmental Regulation of Homeostatic Plasticity in Mouse Primary Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Cortical and Subcortical Circuits for Cross-Modal Plasticity Induced by Loss of Vision.Frontiers in neural circuits · 2021Article
- Numerical Simulation: Fluctuation in Background Synaptic Activity Regulates Synaptic Plasticity.Frontiers in systems neuroscience · 2021Article
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- Endocannabinoid Signaling Contributes to Experience-Induced Increase of Synaptic Release Sites From Parvalbumin Interneurons in Mouse Visual Cortex.Frontiers in cellular neuroscience · 2020Article
- Co-opting evo-devo concepts for new insights into mechanisms of behavioural diversity.The Journal of experimental biology · 2019Review
- Retinoic Acid Receptor RARα-Dependent Synaptic Signaling Mediates Homeostatic Synaptic Plasticity at the Inhibitory Synapses of Mouse Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Enhanced postsynaptic inhibitory strength in hippocampal principal cells in high-performing aged rats.Neurobiology of aging · 2018Article
- Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- Integrating Hebbian and homeostatic plasticity: introduction.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Synapses are intrinsically 'noisy' in that neurotransmitter is occasionally released in the absence of an action potential. At inhibitory synapses, the frequency of action potential-independent release is orders of magnitude higher than that at excitatory synapses raising speculations that it may serve a function. Here we report that the frequency of action potential-independent inhibitory synaptic 'noise' (i.e. miniature inhibitory postsynaptic currents, mIPSCs) is highly regulated by sensory experience in visual cortex. Importantly, regulation of mIPSC frequency is so far the predominant form of functional plasticity at inhibitory synapses in adults during the refractory period for plasticity and is a locus of rapid non-genomic actions of oestrogen. Models predict that regulating the frequency of mIPSCs, together with the previously characterized synaptic scaling of miniature excitatory PSCs, allows homeostatic maintenance of both the mean and variance of inputs to a neuron, a necessary feature of probabilistic population codes. Furthermore, mIPSC frequency regulation allows preservation of the temporal profile of neural responses while homeostatically regulating the overall firing rate. Our results suggest that the control of inhibitory 'noise' allows adaptive maintenance of adult cortical function in tune with the sensory environment.This article is part of the themed issue 'Integrating Hebbian and homeostatic plasticity'.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.