ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2017
A metaplasticity view of the interaction between homeostatic and Hebbian plasticity.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- A Time-Sensitive Plasticity Distinguishes the Rapid and Sustained Synaptic Actions of Ketamine from Its (2The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Understanding amblyopia from the perspective of neurovascular units: changes in the retina and brain.Frontiers in cell and developmental biology · 2025Review
- Interplay of hippocampal long-term potentiation and long-term depression in enabling memory representations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Article
- Harnessing brain plasticity to improve binocular vision in amblyopia: An evidence-based update.European journal of ophthalmology · 2024Review
- Systemic pharmacological suppression of neural activity reverses learning impairment in a mouse model of Fragile X syndrome.bioRxiv : the preprint server for biology · 2024Article
- Rewiring the disordered connectome with circuit-based paired stimulation after stroke-a randomized, double-blind and controlled Phase II trial.Brain communications · 2024Article
- Contribution of membrane-associated oscillators to biological timing at different timescales.Frontiers in physiology · 2023Article
- Effect of acupuncture on BDNF signaling pathways in several nervous system diseases.Frontiers in neurology · 2023Review
- Top-down and bottom-up stimulation techniques combined with action observation treatment in stroke rehabilitation: a perspective.Frontiers in neurology · 2023Review
- Spinal cord retinoic acid receptor signaling gates mechanical hypersensitivity in neuropathic pain.Neuron · 2022Article
- Stability and learning in excitatory synapses by nonlinear inhibitory plasticity.PLoS computational biology · 2022Article
- Homeostatic plasticity and excitation-inhibition balance: The good, the bad, and the ugly.Current opinion in neurobiology · 2022Review
- Movement-dependent electrical stimulation for volitional strengthening of cortical connections in behaving monkeys.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- RETRACTED: Neuroinflammatory Markers: Key Indicators in the Pathology of Neurodegenerative Diseases.Molecules (Basel, Switzerland) · 2022Review
- Postsynaptic Potential Energy as Determinant of Synaptic Plasticity.Frontiers in computational neuroscience · 2022Article
- Effectiveness of contralaterally controlled functional electrical stimulation vs. neuromuscular electrical stimulation for recovery of lower extremity function in patients with subacute stroke: A randomized controlled trial.Frontiers in neurology · 2022Article
- Anterograde interference emerges along a gradient as a function of task similarity: A behavioural study.The European journal of neuroscience · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Hebbian and homeostatic plasticity are two major forms of plasticity in the nervous system: Hebbian plasticity provides a synaptic basis for associative learning, whereas homeostatic plasticity serves to stabilize network activity. While achieving seemingly very different goals, these two types of plasticity interact functionally through overlapping elements in their respective mechanisms. Here, we review studies conducted in the mammalian central nervous system, summarize known circuit and molecular mechanisms of homeostatic plasticity, and compare these mechanisms with those that mediate Hebbian plasticity. We end with a discussion of 'local' homeostatic plasticity and the potential role of local homeostatic plasticity as a form of metaplasticity that modulates a neuron's future capacity for Hebbian plasticity.This article is part of the themed issue 'Integrating Hebbian and homeostatic plasticity'.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.