ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2017
Functional consequences of pre- and postsynaptic expression of synaptic plasticity.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Pooled it
- Article
- Membrane trafficking of synaptic adhesion molecules.The Journal of physiology · 2025Review
- Principles of visual cortex excitatory microcircuit organization.Innovation (Cambridge (Mass.)) · 2025Article
- The spike-timing-dependent plasticity of VIP interneurons in motor cortex.Frontiers in cellular neuroscience · 2024Article
- Pre- and postsynaptic N-methyl-D-aspartate receptors are required for sequential printing of fear memory engrams.iScience · 2023Article
- Presynaptic Protein Synthesis in Brain Function and Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Fully-primed slowly-recovering vesicles mediate presynaptic LTP at neocortical neurons.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Elucidating the neurological mechanism of the FLASH effect in juvenile mice exposed to hypofractionated radiotherapy.Neuro-oncology · 2023Article
- Predictable Fluctuations in Excitatory Synaptic Strength Due to Natural Variation in Presynaptic Firing Rate.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Pre- and postsynaptically expressed spike-timing-dependent plasticity contribute differentially to neuronal learning.PLoS computational biology · 2022Article
- The regulatory role of NAAG-mGluR3 signaling on cortical synaptic plasticity after hypoxic ischemia.Cell communication and signaling : CCS · 2022Article
- GABA Modulates Frequency-Dependent Plasticity in Humans.iScience · 2020Article
- Modeling the Short-Term Dynamics ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Identifiability of a Binomial Synapse.Frontiers in computational neuroscience · 2020Article
- Functional strengthening through synaptic scaling upon connectivity disruption in neuronal cultures.Network neuroscience (Cambridge, Mass.) · 2020Article
- Editorial: Methods for Synaptic Interrogation.Frontiers in synaptic neuroscience · 2020Article
- A Practical Guide to Using CV Analysis for Determining the Locus of Synaptic Plasticity.Frontiers in synaptic neuroscience · 2020Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
Abstract
Growing experimental evidence shows that both homeostatic and Hebbian synaptic plasticity can be expressed presynaptically as well as postsynaptically. In this review, we start by discussing this evidence and methods used to determine expression loci. Next, we discuss the functional consequences of this diversity in pre- and postsynaptic expression of both homeostatic and Hebbian synaptic plasticity. In particular, we explore the functional consequences of a biologically tuned model of pre- and postsynaptically expressed spike-timing-dependent plasticity complemented with postsynaptic homeostatic control. The pre- and postsynaptic expression in this model predicts (i) more reliable receptive fields and sensory perception, (ii) rapid recovery of forgotten information (memory savings), and (iii) reduced response latencies, compared with a model with postsynaptic expression only. Finally, we discuss open questions that will require a considerable research effort to better elucidate how the specific locus of expression of homeostatic and Hebbian plasticity alters synaptic and network computations.This article is part of the themed issue 'Integrating Hebbian and homeostatic plasticity'.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.