Evidence map›Paper›PMID 28093457›Full record

ArticleBioscience reports2017

Functional analysis of the mammalian RNA ligase for IRE1 in the unfolded protein response.

Juthakorn Poothong, Witoon Tirasophon, Randal J Kaufman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioscience reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Insights into the structure and function of the RNA ligase RtcB.Cellular and molecular life sciences : CMLS · 2023
    Review
  2. Regulation of Archease by the mTOR-vATPase axis.Development (Cambridge, England) · 2022
    Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Juthakorn PoothongInstitute of Molecular Biosciences, Mahidol University, Salaya, Nakhon Pathom 73170, Thailand.
Witoon TirasophonInstitute of Molecular Biosciences, Mahidol University, Salaya, Nakhon Pathom 73170, Thailand witoon.mu@gmail.com rkaufman@sbpdiscovery.org.
Randal J KaufmanDegenerative Diseases Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Rd., La Jolla, CA 92037, U.S.A. witoon.mu@gmail.com rkaufman@sbpdiscovery.org.
Mahidol University · TH

Funding

Tumor Microenvironment and Cancer ImmunologyP30CA030199 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Michael Jackson · 1985 to 2026
$107.2M
Role of the Unfolded Protein Response in Beta CellR37DK042394 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KAUFMAN, RANDAL J. · 2007 to 2016
$4.9M
Modifiers of Proinsulin Influence T2D SusceptibilityR24DK110973 · NIDDK · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI ARVAN, PETER, ITKIN-ANSARI, PAMELA ROSE · 2016 to 2019
$4.1M
ER stress and UPR in non-alcoholic steatohepatitis and hepatocellular carcinomaR01CA198103 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI KAUFMAN, RANDAL J. · 2016 to 2020
$3.4M
Homeostatic Role of IRE1a-XBP1-PDI1 in Hepatic Lipid MetabolismR01DK103185 · NIDDK · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI KAUFMAN, RANDAL J. · 2015 to 2019
$2.9M
NCI NIH HHS P30 CA030199NCI NIH HHS R01 CA198103NIDDK NIH HHS R01 DK103185NIDDK NIH HHS R24 DK110973NIDDK NIH HHS R37 DK042394
6 · The paper itself

Abstract

The unfolded protein response (UPR) is a conserved signalling pathway activated on the accumulation of unfolded proteins within the endoplasmic reticulum (ER), termed ER stress. Upon ER stress,

Indexed as

AnimalsBasic-Leucine Zipper Transcription FactorsDNA-Binding ProteinsEndoplasmic ReticulumEndoplasmic Reticulum StressEscherichia coliExonsHumansIntronsLigasesMammalsMembrane GlycoproteinsProtein Serine-Threonine KinasesRepressor ProteinsRNA, MessengerRNA SplicingBasic-Leucine Zipper Transcription FactorsDNA-Binding ProteinsHAC1 protein, S cerevisiaeIRE1 protein, S cerevisiaeLigasesMembrane GlycoproteinsProtein Serine-Threonine KinasesRepressor ProteinsRNA, MessengerSaccharomyces cerevisiae ProteinsX-Box Binding Protein 1archeasehuman IRE1α/XBP1human RtcBrlg1-100Rlg1p

Identifiers

PMID28093457
PMCPMC5333776
OpenAlexW2572006465

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.