ReviewMicrobes and infection
Activation and pathogenic manipulation of the sensors of the innate immune system.
Review in Microbes and infection. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Identifying RNA Sensors in Antiviral Innate Immunity.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Double-Edged Sword: Exploring the Mitochondria-Complement Bidirectional Connection in Cellular Response and Disease.Biology · 2024Review
- Tumor Necrosis Factor-α Receptor 1 Mediates Borna Disease Virus 1-Induced Changes in Peroxisomal and Mitochondrial Dynamics in Neurons.International journal of molecular sciences · 2024Article
- Complement: Functions, location and implications.Immunology · 2023Review
- Immune Functions of Astrocytes in Viral Neuroinfections.International journal of molecular sciences · 2023Review
- Complement's favourite organelle-Mitochondria?British journal of pharmacology · 2021Review
- Strategies for Enhancement of Live-AttenuatedVaccines · 2021Review
- Regulation of Tripartite Motif-Containing Proteins on Immune Response and Viral Evasion.Frontiers in microbiology · 2021Review
- Interferons: Tug of War Between Bacteria and Their Host.Frontiers in cellular and infection microbiology · 2021Review
- Complement Has Brains-Do Intracellular Complement and Immunometabolism Cooperate in Tissue Homeostasis and Behavior?Frontiers in immunology · 2021Review
- Asymmetric distribution of TLR3 leads to a polarized immune response in human intestinal epithelial cells.Nature microbiology · 2020Article
- The commensal bacterium Bacteroides fragilis down-regulates ferroportin expression and alters iron homeostasis in macrophages.Journal of leukocyte biology · 2019Article
- Mouse protein coding diversity: What's left to discover?PLoS genetics · 2019Review
- Evolution of negative immune regulators.PLoS pathogens · 2019Article
- Alternative splicing regulates stochastic NLRP3 activity.Nature communications · 2019Article
- Bacteriophage T4 nanoparticles for vaccine delivery against infectious diseases.Advanced drug delivery reviews · 2019Review
- TRIM21-From Intracellular Immunity to Therapy.Frontiers in immunology · 2019Review
- Article
- Intracellular Antiviral Immunity.Advances in virus research · 2018Review
- Reovirus inhibits interferon production by sequestering IRF3 into viral factories.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The innate immune system detects the presence of microbes through different families of pattern-recognition receptors (PRRs). PRRs detect pathogens of all origins and trigger signaling events that activate innate and adaptive immunity. These events need to be tightly regulated in order to ensure optimal activation when required, and minimal signaling in the absence of microbial encounters. This regulation is achieved, at least in part, through the precise subcellular positioning of receptors and downstream signaling proteins. Consequently, mislocalization of these proteins inhibits innate immune pathways, and pathogens have evolved to alter host protein localization as a strategy to evade immune detection. This review describes the importance of subcellular localization of various PRR families and their adaptors, and highlights pathogenic immune evasion strategies that operate by altering immune protein localization.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.