ArticleBMC oral health2017
Assessing the progression of chronic periodontitis using subgingival pathogen levels: a 24-month prospective multicenter cohort study.
Article in BMC oral health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Microbial Markers for Diagnosis and Risk Assessment for Periodontal Diseases: A Systematic Literature Search and Narrative Synthesis.Journal of clinical periodontology · 2025Pooled it
- Measuring the Invisible: Microbial Diagnostics for Periodontitis-A Narrative Review.International journal of molecular sciences · 2025Review
- Development of a Versatile, Low-Cost Electrochemical System to Study Biofilm Redox Activity at the Micron Scale.Applied and environmental microbiology · 2022Article
- Treatment resistance of rheumatoid arthritis relates to infection of periodontal pathogenic bacteria: a case-control cross-sectional study.Scientific reports · 2022Article
- Effect of Locally Delivered Minocycline on the Profile of Subgingival Bacterial Genera in Patients with Periodontitis: A Prospective Pilot Study.Biomolecules · 2022Article
- Prospective Longitudinal Changes in the Periodontal Inflamed Surface Area Following Active Periodontal Treatment for Chronic Periodontitis.Journal of clinical medicine · 2021Article
- Estimation of the Periodontal Inflamed Surface Area by Simple Oral Examination.Journal of clinical medicine · 2021Article
- Optimal Examination Sites for Periodontal Disease Evaluation: Applying the Item Response Theory Graded Response Model.Journal of clinical medicine · 2020Article
- Salivary markers of oxidative stress and periodontal pathogens in patients with periodontitis from Santander, Colombia.Biomedica : revista del Instituto Nacional de Salud · 2020Article
- Pathogen profile and MMP-3 levels in areas with varied attachment loss in generalized aggressive and chronic periodontitis.Central-European journal of immunology · 2019Article
- Willingness to Work and the Working Environment of Japanese Dental Hygienists.International journal of dentistry · 2018Article
- The effects of different restorative materials on periodontopathogens in combined restorative-periodontal treatment.Journal of applied oral science : revista FOB · 2018Article
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Corrections and comments
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Authors and funding
37 authors at 17 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe diagnosis of the progression of periodontitis presently depends on the use of clinical symptoms (such as attachment loss) and radiographic imaging. The aim of the multicenter study described here was to evaluate the diagnostic use of the bacterial content of subgingival plaque recovered from the deepest pockets in assessing disease progression in chronic periodontitis patients.
methodsThis study consisted of a 24-month investigation of a total of 163 patients with chronic periodontitis who received trimonthly follow-up care. Subgingival plaque from the deepest pockets was recovered and assessed for bacterial content of Porphyromonas gingivalis, Prevotella intermedia, and Aggregatibacter actinomycetemcomitans using the modified Invader PLUS assay. The corresponding serum IgG titers were measured using ELISA. Changes in clinical parameters were evaluated over the course of 24 months. The sensitivity, specificity, and prediction values were calculated and used to determine cutoff points for prediction of the progression of chronic periodontitis.
resultsOf the 124 individuals who completed the 24-month monitoring phase, 62 exhibited progression of periodontitis, whereas 62 demonstrated stable disease. The P. gingivalis counts of subgingival plaque from the deepest pockets was significantly associated with the progression of periodontitis (p < 0.001, positive predictive value = 0.708).
conclusionsThe P. gingivalis counts of subgingival plaque from the deepest pockets may be associated with the progression of periodontitis.
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