Evidence map›Paper›PMID 28092786›Full record

ArticleJournal of magnetic resonance (San Diego, Calif. : 1997)2017

Imaging thiol redox status in murine tumors in vivo with rapid-scan electron paramagnetic resonance.

Boris Epel, Subramanian V Sundramoorthy, Martyna Krzykawska-Serda, Matthew C Maggio, Mark Tseytlin, Gareth R Eaton, Sandra S Eaton, Gerald M Rosen, Joseph P Y Kao, Howard J Halpern

Open access · greenAbstract read
In one paragraph

Article in Journal of magnetic resonance (San Diego, Calif. : 1997), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
8.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 52 citations in OpenAlex.

  1. Review
  2. Advances in redox imaging for cancer diagnosis and therapy.Journal of clinical biochemistry and nutrition · 2026
    Article
  3. Reconfigurable animal bed-EPR resonator assembly for multimodal co-registration.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2026
    Article
  4. Computationally efficient 4D spectral-spatial EPR imaging.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Quantum Mimicry With Inorganic Chemistry.Comments on modern chemistry. Part A, Comments on inorganic chemistry : a journal of critical discussion of the current literature · 2024
    Article
  9. Article
  10. Article
  11. Rapid scan EPR: Automated digital resonator control for low-latency data acquisition.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2022
    Article
  12. Ligand design of zero-field splitting in trigonal prismatic Ni(II) cage complexes.Dalton transactions (Cambridge, England : 2003) · 2022
    Article
  13. Advances in rapid scan EPR spectroscopy.Methods in enzymology · 2022
    Article
  14. Article
  15. High fidelity triangular sweep of the magnetic field for millisecond scan EPR imaging.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2021
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. General solution for rapid scan EPR deconvolution problem.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Boris EpelCenter for EPR Imaging In Vivo Physiology, Department of Radiation and Cellular Oncology, University of Chicago, IL, USA.
Subramanian V SundramoorthyCenter for EPR Imaging In Vivo Physiology, Department of Radiation and Cellular Oncology, University of Chicago, IL, USA.
Martyna Krzykawska-SerdaCenter for EPR Imaging In Vivo Physiology, Department of Radiation and Cellular Oncology, University of Chicago, IL, USA.
Matthew C MaggioCenter for EPR Imaging In Vivo Physiology, Department of Radiation and Cellular Oncology, University of Chicago, IL, USA.
Mark TseytlinDepartment of Biochemistry, School of Medicine, University of West Virginia, Morgantown, WV 26506, USA.
Gareth R EatonDepartment of Chemistry and Biochemistry, University of Denver, Denver, CO 80208, USA.
Sandra S EatonDepartment of Chemistry and Biochemistry, University of Denver, Denver, CO 80208, USA.
Gerald M RosenDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.
Joseph P Y KaoCenter for Biomedical Engineering & Technology, and Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Howard J HalpernCenter for EPR Imaging In Vivo Physiology, Department of Radiation and Cellular Oncology, University of Chicago, IL, USA. Electronic address: h-halpern@uchicago.edu.
University of Chicago · USUniversity of Denver · USUniversity of Maryland, Baltimore · USWest Virginia University · US

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Sally Lynn Hodder · 2012 to 2026
$81.0M
Very Low Frequency EPR Imaging in Vivo Phisiology P41 EB02034P41EB002034 · NIBIB · UNIVERSITY OF CHICAGO · PI HALPERN, HOWARD J · 2003 to 2017
$16.1M
Radiation Biology of EPR Oxygen ImagesR01CA098575 · NCI · UNIVERSITY OF CHICAGO · PI HALPERN, HOWARD J · 2003 to 2022
$4.5M
CAGED PROBES FOR CELLULAR PHYSIOLOGYR01GM056481 · NIGMS · UNIVERSITY OF MD BIOTECHNOLOGY INSTITUTE · PI KAO, JOSEPH PAO YUNG · 1998 to 2009
$3.3M
Preclinical Electron Paramagnetic Resonance Tumor ImagerR01CA177744 · NCI · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI EATON, GARETH R · 2014 to 2019
$2.7M
Optimization of Cancer Therapy guided by oxygen, pH, thiol and other parametric imagesR50CA211408 · NCI · UNIVERSITY OF CHICAGO · PI EPEL, BORIS · 2016 to 2020
$637k
Multifunctional in Vivo EPR Imaging of Tumor MicroenvironmentR21EB022775 · NIBIB · WEST VIRGINIA UNIVERSITY · PI TSEYTLIN, MARK · 2016 to 2017
$427k
Enhancing in vivo EPR imaging using spin probes with short relaxation timesK25EB016040 · NIBIB · WEST VIRGINIA UNIVERSITY · PI TSEYTLIN, MARK · 2013 to 2015
$416k
NCI NIH HHS R01 CA098575NCI NIH HHS R01 CA177744NCI NIH HHS R50 CA211408NIBIB NIH HHS K25 EB016040NIBIB NIH HHS P41 EB002034NIBIB NIH HHS R21 EB022775NIGMS NIH HHS R01 GM056481NIGMS NIH HHS U54 GM104942
6 · The paper itself

Abstract

Thiol redox status is an important physiologic parameter that affects the success or failure of cancer treatment. Rapid scan electron paramagnetic resonance (RS EPR) is a novel technique that has shown higher signal-to-noise ratio than conventional continuous-wave EPR in in vitro studies. Here we used RS EPR to acquire rapid three-dimensional images of the thiol redox status of tumors in living mice. This work presents, for the first time, in vivo RS EPR images of the kinetics of the reaction of

Indexed as

AnimalsBrain NeoplasmsButhionine SulfoximineDiagnostic ImagingDisulfidesElectron Spin Resonance SpectroscopyFemaleFibrosarcomaGlutathioneImaging, Three-DimensionalKineticsMiceMice, Inbred C3HNeoplasms, ExperimentalNitrogen OxidesOxidation-ReductionButhionine SulfoximineDisulfidesGlutathioneNitrogen OxidesSpin LabelsElectron paramagnetic resonanceEPR imagingGlutathioneRapid scan EPRThiol redox status

Identifiers

PMID28092786
PMCPMC5336491
OpenAlexW2565232113

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.