ArticleNature medicine2017
Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states.
2 registry-linked trialsOpen access · greenAbstract read
In one paragraph
Article in Nature medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 237 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
237citing papers in PubMed, 3 pooled it
18.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Immune Senescence in the Elderly: Comparison of Immune Responses to Influenza Vaccine In Adults of Different Ages
Residual Immune Activation in HIV-infected Patients on Successful cART: Association Between Inflammasome Activation in Monocytes by Circulating Metabolites and Non AIDS Defining Comorbidities
Who cites it
237 citing papers in PubMed, 3 syntheses or guidelines pooled it, 387 citations in OpenAlex.
- Analysis of genetically determined gene expression suggests role of inflammatory processes in exfoliation syndrome.BMC genomics · 2023Pooled it
- Effects of Resistance Training on C-Reactive Protein and Inflammatory Cytokines in Elderly Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.International journal of environmental research and public health · 2022Pooled it
- Blood DNA methylation sites predict death risk in a longitudinal study of 12, 300 individuals.Aging · 2020Pooled it
- Oats Lower Age-Related Systemic Chronic Inflammation (iAge) in Adults at Risk for Cardiovascular Disease.Nutrients · 2022Trial
- The Effect of Weaning with Adult Food Typical of the Mediterranean Diet on Taste Development and Eating Habits of Children: A Randomized Trial.Nutrients · 2022Trial
- Hepatitis C Virus (HCV) Direct-Acting Antiviral Therapy in Persons With Human Immunodeficiency Virus-HCV Genotype 1 Coinfection Resulting in High Rate of Sustained Virologic Response and Variable in Normalization of Soluble Markers of Immune Activation.The Journal of infectious diseases · 2020Trial
- Remodeling of innate antiviral immunity in aging.Cell insight · 2026Review
- Comparative study on the predictive value of PNI and GNRI for all-cause mortality rates of elderly patients in cardiac care unit and cardiovascular intensive care unit.European journal of clinical nutrition · 2026Observational
- The role of Dymeclin in chronic unpredictable mild stress-induced depression: maintaining the Golgi apparatus structure and regulating NLRP3 inflammasome activation.Molecular medicine (Cambridge, Mass.) · 2026Article
- Associations of systemic inflammatory indices and metabolically healthy vs. unhealthy obesity in children.Italian journal of pediatrics · 2026Article
- Inflammation-modulating agents in chronic limb-threatening ischemia: a narrative review of therapeutic potential and future directions.Annals of medicine and surgery (2012) · 2026Article
- Age- and Genotype-Associated Specific Expression of IL-1 and TNF Receptors on Immunocompetent Cells.International journal of molecular sciences · 2026Article
- Sjögren's disease metabolome reveals biomarker signatures to characterise patients and assess disease activity.RMD open · 2026Article
- Calcium Carbonate-Stabilized Nano-Caffeine Emulsion Attenuates Diabetic Cardiomyopathy via Antioxidant, Anti-Inflammatory, and Anti-Fibrotic Pathways in Type 2 Diabetic Rats with HPLC-Quantified Cardiac Caffeine Levels.International journal of nanomedicine · 2026Article
- Tubular NAT10 Promotes the Secretion of TGF-β and Lactate to Drive Fibroblast Activation in Diabetic Kidney Disease.International journal of biological sciences · 2026Article
- Research progress on the role and mechanisms of ferroptosis in diabetic wound repair.Cell death discovery · 2025Review
- Age-Associated Inflammatory Monocytes Are Increased in Menopausal Females and Reversed by Hormone Replacement Therapy.Aging cell · 2025Article
- Two-phase model of ageing in mice for improved identification of age-related and late life metabolic decline.BMC biology · 2025Article
- Adipocyte FMO3-derived TMAO induces WAT dysfunction and metabolic disorders by promoting inflammasome activation in ageing.Nature communications · 2025Article
- Exploration of Biomarkers of Food Intake in a Caribbean Hispanic Population.Molecular nutrition & food research · 2025Article
177 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
20 authors at 6 institutions in 3 countries.
David FurmanInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, California, USA.
Junlei ChangDepartment of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, California, USA.
Lydia LartigueINSERM U916 VINCO, Institut Bergonié, Bordeaux Cedex, France.
Christopher R BolenDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA.
François HaddadInstitute of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA.
Brice GaudilliereDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA.
Edward A GanioDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA.
Gabriela K FragiadakisDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA.
Matthew H SpitzerDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA.
Isabelle DouchetCIRID, UMR CNRS 5164, Université Bordeaux 2, Bordeaux Cedex, France.
Sophie DaburonCIRID, UMR CNRS 5164, Université Bordeaux 2, Bordeaux Cedex, France.
Jean-François MoreauCIRID, UMR CNRS 5164, Université Bordeaux 2, Bordeaux Cedex, France.
Garry P NolanDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA.
Patrick BlancoCIRID, UMR CNRS 5164, Université Bordeaux 2, Bordeaux Cedex, France.
Julie Déchanet-MervilleCIRID, UMR CNRS 5164, Université Bordeaux 2, Bordeaux Cedex, France.
Cornelia L DekkerDepartment of Pediatrics, Division of Infectious Diseases, Stanford University, Stanford, California, USA.
Vladimir JojicDepartment of Computer Science, University of North Carolina, Chapel Hill, North Carolina, USA.
Calvin J KuoDepartment of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, California, USA.
Mark M DavisInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, California, USA.
Benjamin FaustinCIRID, UMR CNRS 5164, Université Bordeaux 2, Bordeaux Cedex, France.
Stanford University · USCentre National de la Recherche Scientifique · FRHoward Hughes Medical Institute · USInstitut Bergonié · FRUniversité de Bordeaux · FRUniversity of North Carolina at Chapel Hill · US
Funding
Using a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5MVaccination and infection: indicators of immunological health and responsivenessU19AI090019 · NIAID · STANFORD UNIVERSITY · PI DAVIS, MARK MORRIS · 2010 to 2015
$17.3MRole of Myeloid Derived Suppressor Cells in the Immune Response to SurgeryK23GM111657 · NIGMS · STANFORD UNIVERSITY · PI GAUDILLIERE, BRICE · 2014 to 2017
$524kNIAID NIH HHS U19 AI057229NIAID NIH HHS U19 AI090019NIGMS NIH HHS K23 GM111657
Abstract
Low-grade, chronic inflammation has been associated with many diseases of aging, but the mechanisms responsible for producing this inflammation remain unclear. Inflammasomes can drive chronic inflammation in the context of an infectious disease or cellular stress, and they trigger the maturation of interleukin-1β (IL-1β). Here we find that the expression of specific inflammasome gene modules stratifies older individuals into two extremes: those with constitutive expression of IL-1β, nucleotide metabolism dysfunction, elevated oxidative stress, high rates of hypertension and arterial stiffness; and those without constitutive expression of IL-1β, who lack these characteristics. Adenine and N
Indexed as
AdenineAdultAgedAged, 80 and overAgingAnimalsBlood PlateletsBlood PressureCaffeineCalcium-Binding ProteinsCARD Signaling Adaptor ProteinsCarotid Intima-Media ThicknessCell LineCytidineCytokinesFemaleAdenineCaffeineCalcium-Binding ProteinsCARD Signaling Adaptor ProteinsCytidineCytokinesIL1B protein, humanIL1B protein, mouseIL1RN protein, humanInflammasomesInterleukin-1betaInterleukin 1 Receptor Antagonist ProteinIntracellular Signaling Peptides and ProteinsN-acetylcytidineNLRC4 protein, humanNLRC5 protein, humanNucleotidesPurinergic P1 Receptor AntagonistsTLR5 protein, humanTLR6 protein, humanTLR8 protein, humanToll-Like Receptor 5Toll-Like Receptor 6Toll-Like Receptor 8
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
NCT01827462ClinicalTrials.gov
NCT03191175ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.