Evidence map›Paper›PMID 28092661›Full record

ReviewNature neuroscience2017

Interactions between the microbiota, immune and nervous systems in health and disease.

Thomas C Fung, Christine A Olson, Elaine Y Hsiao

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03612193 (Role of the Gut Microbiome in Complex Regional Pain Syndrome), which is not on this map. Cited by 1,005 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,005citing papers in PubMed, 7 pooled it
61.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03612193 recruitingnot on this mapstarted 2018, after this paper: background citation

Role of the Gut Microbiome in Complex Regional Pain Syndrome

TypeobservationalSponsorWashington University School of MedicineRan2018 to 2027Enrolled140ConditionsComplex Regional Pain Syndromes
3 · Its place in the literature

Who cites it

1,005 citing papers in PubMed, 7 syntheses or guidelines pooled it, 1,863 citations in OpenAlex.

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945 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Thomas C FungDepartment of Integrative Biology &Physiology, University of California Los Angeles, Los Angeles, California, USA.
Christine A OlsonDepartment of Integrative Biology &Physiology, University of California Los Angeles, Los Angeles, California, USA.
Elaine Y HsiaoDepartment of Integrative Biology &Physiology, University of California Los Angeles, Los Angeles, California, USA.
University of California, Los Angeles · US

Funding

Training in Molecular, Cellular &Integrative PhysiologyT32GM065823 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TIDBALL, JAMES G · 2003 to 2017
$2.1M
Uncovering microbial modulators of neuroactive molecules as novel therapeutics.DP5OD017924 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HSIAO, ELAINE · 2013 to 2017
$1.9M
Functional Role of IL-6 in Fetal Brain Development and Abnormal BehaviorF31MH090749 · NIMH · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI HSIAO, ELAINE · 2011 to 2012
$64k
NIGMS NIH HHS T32 GM065823NIH HHS DP5 OD017924NIMH NIH HHS F31 MH090749
6 · The paper itself

Abstract

The diverse collection of microorganisms that inhabit the gastrointestinal tract, collectively called the gut microbiota, profoundly influences many aspects of host physiology, including nutrient metabolism, resistance to infection and immune system development. Studies investigating the gut-brain axis demonstrate a critical role for the gut microbiota in orchestrating brain development and behavior, and the immune system is emerging as an important regulator of these interactions. Intestinal microbes modulate the maturation and function of tissue-resident immune cells in the CNS. Microbes also influence the activation of peripheral immune cells, which regulate responses to neuroinflammation, brain injury, autoimmunity and neurogenesis. Accordingly, both the gut microbiota and immune system are implicated in the etiopathogenesis or manifestation of neurodevelopmental, psychiatric and neurodegenerative diseases, such as autism spectrum disorder, depression and Alzheimer's disease. In this review, we discuss the role of CNS-resident and peripheral immune pathways in microbiota-gut-brain communication during health and neurological disease.

Indexed as

AnimalsAutism Spectrum DisorderAutoimmunityBrainGastrointestinal TractHumansMicrobiotaNervous System Diseases

Identifiers

PMID28092661
PMCPMC6960010
OpenAlexW2572551054

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.