Phenotypes and treatment response: it's difficult to make predictions, especially about the future.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

14 citing papers in PubMed.

1. Essential statistical principles of clinical trials of pain treatments.Pain reports
   Trial
2. The ACTTION Guide to Clinical Trials of Pain Treatments, part II: mitigating bias, maximizing value.Pain reports
   Trial
3. Dynamic coupling of emotion and pain: from perception to affective response.The Korean journal of pain · 2026
   Review
4. Clinical predictors of treatment response to gabapentin in women with unexplained chronic pelvic pain.Frontiers in pharmacology · 2024
   Article
5. Placebo effects in osteoarthritis: implications for treatment and drug development.Nature reviews. Rheumatology · 2023
   Review
6. Evaluation of a Clustering Approach to Define Distinct Subgroups of Patients With Migraine to Select Electroacupuncture Treatments.Neurology · 2023
   Article
7. Neuropathic Pain and Spinal Cord Injury: Management, Phenotypes, and Biomarkers.Drugs · 2023
   Review
8. Predicting Treatment Responses in Patients With Osteoarthritis: Results From Two Phase III Tanezumab Randomized Clinical Trials.Clinical pharmacology and therapeutics · 2023
   Article
9. John D. Loeser Award Lecture: Size does matter, but it isn't everything: the challenge of modest treatment effects in chronic pain clinical trials.Pain · 2020
   Article
10. Navigating trials of personalized pain treatments: we're going to need a bigger boat.Pain · 2019
    Review
11. Stratifying patients with peripheral neuropathic pain based on sensory profiles: algorithm and sample size recommendations.Pain · 2017
    Article
12. Neuropathic Pain and Spinal Cord Injury: Phenotypes and Pharmacological Management.Drugs · 2017
    Review
13. Designing and conducting proof-of-concept chronic pain analgesic clinical trials.Pain reports
    Article
14. Human-like cutaneous neuropathologies associated with a porcine model of peripheral neuritis: A translational platform for neuropathic pain.Neurobiology of pain (Cambridge, Mass.)
    Article

Corrections and comments

• Comment on
  Peripheral neuropathic pain: a mechanism-related organizing principle based on sensory profiles.2017

Authors and funding

2 authors.

Funding

Abstract

PubMed holds no abstract for this paper.