Evidence map›Paper›PMID 28092368›Full record

ArticleNature structural & molecular biology2017

Molecular insights into lipid-assisted Ca

Martin Wilkes, M Gregor Madej, Lydia Kreuter, Daniel Rhinow, Veronika Heinz, Silvia De Sanctis, Sabine Ruppel, Rebecca M Richter, Friederike Joos, Marina Grieben and 6 more

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Nature structural & molecular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed
17.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 127 citations in OpenAlex.

  1. Article
  2. AbioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. A synthetic method to assay polycystin channel biophysics.bioRxiv : the preprint server for biology · 2024
    Article
  10. Article
  11. Review
  12. Review
  13. Vascular polycystin proteins in health and disease.Microcirculation (New York, N.Y. : 1994) · 2024
    Review
  14. Article
  15. Molecular and structural basis of the dual regulation of the polycystin-2 ion channel by small-molecule ligands.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  16. Article
  17. Review
  18. Article
  19. Polycystin Channel Complexes.Annual review of physiology · 2023
    Review
  20. A Structural Overview of TRPML1 and the TRPML Family.Handbook of experimental pharmacology · 2023
    Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Martin WilkesMax Planck Institute of Biophysics, Department of Structural Biology, Frankfurt, Germany.
M Gregor MadejBiophysics II, Faculty of Biology and Preclinical Medicine, Regensburg, Germany.ORCID 0000-0001-9181-6387
Lydia KreuterBiophysics II, Faculty of Biology and Preclinical Medicine, Regensburg, Germany.
Daniel RhinowMax Planck Institute of Biophysics, Department of Structural Biology, Frankfurt, Germany.
Veronika HeinzBiophysics II, Faculty of Biology and Preclinical Medicine, Regensburg, Germany.
Silvia De SanctisBiophysics II, Faculty of Biology and Preclinical Medicine, Regensburg, Germany.
Sabine RuppelBiophysics II, Faculty of Biology and Preclinical Medicine, Regensburg, Germany.
Rebecca M RichterBiophysics II, Faculty of Biology and Preclinical Medicine, Regensburg, Germany.
Friederike JoosMax Planck Institute of Biophysics, Department of Structural Biology, Frankfurt, Germany.
Marina GriebenStructural Genomics Consortium, University of Oxford, Oxford, UK.
Ashley C W PikeStructural Genomics Consortium, University of Oxford, Oxford, UK.ORCID 0000-0001-9661-2607
Juha T HuiskonenOxford Particle Imaging Centre, Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID 0000-0002-0348-7323
Elisabeth P CarpenterStructural Genomics Consortium, University of Oxford, Oxford, UK.ORCID 0000-0001-9138-2937
Werner KühlbrandtMax Planck Institute of Biophysics, Department of Structural Biology, Frankfurt, Germany.
Ralph WitzgallDepartment of Anatomy, Faculty of Biology and Preclinical Medicine, Regensburg, Germany.
Christine ZieglerBiophysics II, Faculty of Biology and Preclinical Medicine, Regensburg, Germany.
Max Planck Institute of Biophysics · DEUniversity of Oxford · GBCentre for Human Genetics · GBUniversity of Regensburg · DE

Funding

Wellcome Trust 060208/Z/00/ZWellcome Trust 090532/Z/09/ZWellcome Trust 092809/Z/10/ZWellcome Trust 093305/Z/10/Z
6 · The paper itself

Abstract

Polycystin-2 (PC2), a calcium-activated cation TRP channel, is involved in diverse Ca

Indexed as

Binding SitesCalciumCalcium SignalingCryoelectron MicroscopyGlycosylationHEK293 CellsHumansModels, MolecularPhosphatidic AcidsPhosphatidylcholinesProtein BindingProtein Conformation, alpha-HelicalProtein DomainsProtein Processing, Post-TranslationalProtein Structure, QuaternaryTRPP Cation ChannelsCalciumPhosphatidic AcidsPhosphatidylcholinesTRPP Cation Channels

Identifiers

PMID28092368
OpenAlexW2576388396

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.