ArticleNature chemical biology2017
Designed cell consortia as fragrance-programmable analog-to-digital converters.
Article in Nature chemical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Bacteria as living biosensors for DNA.Nature reviews bioengineering · 2026Article
- Nitroglycerin-responsive gene switch for the on-demand production of therapeutic proteins.Nature biomedical engineering · 2025Article
- Assembly of functional microbial ecosystems: from molecular circuits to communities.FEMS microbiology reviews · 2024Review
- Multicellular artificial neural network-type architectures demonstrate computational problem solving.Nature chemical biology · 2024Article
- An electrogenetic interface to program mammalian gene expression by direct current.Nature metabolism · 2023Article
- Synthetic memory circuits for stable cell reprogramming in plants.Nature biotechnology · 2022Article
- Synthetic neuromorphic computing in living cells.Nature communications · 2022Article
- A single layer artificial neural network type architecture with molecular engineered bacteria for reversible and irreversible computing.Chemical science · 2021Article
- Quantitative characterization of recombinase-based digitizer circuits enables predictable amplification of biological signals.Communications biology · 2021Article
- Design of Multipartite Transcription Factors for Multiplexed Logic Genome Integration Control in Mammalian Cells.ACS synthetic biology · 2020Article
- Protease circuits for processing biological information.Nature communications · 2020Article
- A modular degron library for synthetic circuits in mammalian cells.Nature communications · 2019Article
- An improved Tet-on system in microRNA overexpression and CRISPR/Cas9-mediated gene editing.Journal of animal science and biotechnology · 2019Article
- Designing cell function: assembly of synthetic gene circuits for cell biology applications.Nature reviews. Molecular cell biology · 2018Review
- In vivo biosensors: mechanisms, development, and applications.Journal of industrial microbiology & biotechnology · 2018Article
- Designer cells programming quorum-sensing interference with microbes.Nature communications · 2018Article
- Scaling up genetic circuit design for cellular computing: advances and prospects.Natural computing · 2018Article
- Programmable full-adder computations in communicating three-dimensional cell cultures.Nature methods · 2018Article
- Scaling Computation and Memory in Living Cells.Current opinion in biomedical engineering · 2017Article
- Sensing and responding to allergic response cytokines through a genetically encoded circuit.Nature communications · 2017Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synthetic biology advances the rational engineering of mammalian cells to achieve cell-based therapy goals. Synthetic gene networks have nearly reached the complexity of digital electronic circuits and enable single cells to perform programmable arithmetic calculations or to provide dynamic remote control of transgenes through electromagnetic waves. We designed a synthetic multilayered gaseous-fragrance-programmable analog-to-digital converter (ADC) allowing for remote control of digital gene expression with 2-bit AND-, OR- and NOR-gate logic in synchronized cell consortia. The ADC consists of multiple sampling-and-quantization modules sensing analog gaseous fragrance inputs; a gas-to-liquid transducer converting fragrance intensity into diffusible cell-to-cell signaling compounds; a digitization unit with a genetic amplifier circuit to improve the signal-to-noise ratio; and recombinase-based digital expression switches enabling 2-bit processing of logic gates. Synthetic ADCs that can remotely control cellular activities with digital precision may enable the development of novel biosensors and may provide bioelectronic interfaces synchronizing analog metabolic pathways with digital electronics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.