Trial reportPain2017
Persistent pain after motor vehicle collision: comparative effectiveness of opioids vs nonsteroidal antiinflammatory drugs prescribed from the emergency department-a propensity matched analysis.
Trial report in Pain, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Opioid Analgesic Use After an Acute Pain Visit: Evidence from a Urolithiasis Patient Cohort.The western journal of emergency medicine · 2022Trial
- Peritraumatic C-reactive protein levels predict pain outcomes following traumatic stress exposure in a sex-dependent manner.The journal of pain · 2026Article
- Adverse Drug Events Associated with Opioid Treatment for Pain After Motor Vehicle Crash.Journal of pain research · 2026Article
- Comparing the efficacy of pethidine and ketorolac in managing postoperative pain following orthopedic fracture surgery in addicts: a prospective clinical study.Annals of medicine and surgery (2012) · 2026Article
- Article
- Clinical outcomes and psychosomatic correlates of integrative inpatient care based on Traditional Korean Medicine for acute neck and low back pain following traffic accidents: a retrospective cohort study.Frontiers in medicine · 2025Article
- Abnormal Static Sagittal Cervical Curvatures following Motor Vehicle Collisions: A Retrospective Case Series of 41 Patients before and after a Crash Exposure.Diagnostics (Basel, Switzerland) · 2024Article
- The Pain Management of Trauma Patients in the Emergency Department.Journal of clinical medicine · 2023Review
- Use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort.Translational psychiatry · 2023Article
- Machine learning for improving high-dimensional proxy confounder adjustment in healthcare database studies: An overview of the current literature.Pharmacoepidemiology and drug safety · 2022Review
- Hippocampal volume, FKBP5 genetic risk alleles, and childhood trauma interact to increase vulnerability to chronic multisite musculoskeletal pain.Scientific reports · 2022Article
- Predicting at-risk opioid use three months after ed visit for trauma: Results from the AURORA study.PloS one · 2022Article
- Opioid Analgesics and Persistent Pain After an Acute Pain Emergency Department Visit: Evidence from a Cohort of Suspected Urolithiasis Patients.The Journal of emergency medicine · 2021Article
- Framework for identifying drug repurposing candidates from observational healthcare data.JAMIA open · 2020Article
- Opioid Use During the Six Months After an Emergency Department Visit for Acute Pain: A Prospective Cohort Study.Annals of emergency medicine · 2020Observational
- Clinical Practice Guidelines for Pain Management in Acute Musculoskeletal Injury.Journal of orthopaedic trauma · 2019Review
- Article
- Article
- Management of Whiplash Associated Disorders in Australian general practice.BMC musculoskeletal disorders · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 9 institutions in 1 country.
Funding
Abstract
Each year millions of Americans present to the emergency department (ED) for care after a motor vehicle collision (MVC); the majority (>90%) are discharged to home after evaluation. Acute musculoskeletal pain is the norm in this population, and such patients are typically discharged to home with prescriptions for oral opioid analgesics or nonsteroidal antiinflammatory drugs (NSAIDs). The influence of acute pain management on subsequent pain outcomes in this common ED population is unknown. We evaluated the effect of opioid analgesics vs NSAIDs initiated from the ED on the presence of moderate to severe musculoskeletal pain and ongoing opioid use at 6 weeks in a large cohort of adult ED patients presenting to the ED after MVC (n = 948). The effect of opioids vs NSAIDs was evaluated using an innovative quasi-experimental design method using propensity scores to account for covariate imbalances between the 2 treatment groups. No difference in risk for moderate to severe musculoskeletal pain at 6 weeks was observed between those discharged with opioid analgesics vs NSAIDs (risk difference = 7.2% [95% confidence interval: -5.2% to 19.5%]). However, at follow-up participants prescribed opioids were more likely than those prescribed NSAIDs to report use of prescription opioids medications at week 6 (risk difference = 17.5% [95% confidence interval: 5.8%-29.3%]). These results suggest that analgesic choice at ED discharge does not influence the development of persistent moderate to severe musculoskeletal pain 6 weeks after an MVC, but may result in continued use of prescription opioids. Supported by NIAMS R01AR056328 and AHRQ 5K12HS022998.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.