Evidence map›Paper›PMID 28092267›Full record

ArticleeLife2017

Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating.

Gregory M Martin, Craig Yoshioka, Emily A Rex, Jonathan F Fay, Qing Xie, Matthew R Whorton, James Z Chen, Show-Ling Shyng

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed
20.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 207 citations in OpenAlex.

  1. Treatment of overactive KScientific reports · 2025
    Trial
  2. Trial
  3. Molecular mechanisms of Kir channel gating.Biochemical Society transactions · 2026
    Review
  4. KCNJ11-associated infantile epileptic spasms syndrome and neonatal diabetes.Epileptic disorders : international epilepsy journal with videotape · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Dynamic duo: Kir6 and SUR in KChannels (Austin, Tex.) · 2024
    Review
  12. Article
  13. Article
  14. Article
  15. Structure of an open KNature communications · 2024
    Article
  16. Article
  17. Electro-metabolic signaling.The Journal of general physiology · 2024
    Article
  18. Non-radioactive RbMethods in molecular biology (Clifton, N.J.) · 2024
    Article
  19. Article
  20. Article

48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Gregory M MartinDepartment of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon, United States.
Craig YoshiokaDepartment of Biomedical Engineering, Oregon Health and Science University, Portland, Oregon, United States.
Emily A RexDepartment of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon, United States.
Jonathan F FayDepartment of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon, United States.
Qing XieDepartment of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon, United States.
Matthew R WhortonVollum Institute, Oregon Health and Science University, Portland, Oregon, United States.
James Z ChenDepartment of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon, United States.
Show-Ling ShyngDepartment of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon, United States.ORCID 0000-0002-8230-8820
Oregon Health & Science University · US

Funding

Structural Basis of KATP Channel GatingR01DK066485 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI SHYNG, SHOW-LING · 2006 to 2024
$5.8M
Pharmacological rescue of trafficking-impaired KATP channelsF31DK105800 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI MARTIN, GREGORY M · 2015 to 2017
$131k
NIDDK NIH HHS F31 DK105800NIDDK NIH HHS R01 DK066485
6 · The paper itself

Abstract

K

Indexed as

Cryoelectron MicroscopyAdenosine TriphosphateGlyburideHumansKcnj11 ChannelModels, MolecularPotassium Channels, Inwardly RectifyingProtein ConformationProtein MultimerizationSulfonylurea ReceptorsAbcc8 protein, ratAdenosine TriphosphateGlyburideKcnj11 ChannelPotassium Channels, Inwardly RectifyingSulfonylurea ReceptorsABC transporterATPbiophysicsinward rectifiernonestructural biologysulfonylureasulfonylurea receptor

Identifiers

PMID28092267
PMCPMC5344670
OpenAlexW2574882949

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.