ArticleEJNMMI physics2017
Point-spread function reconstructed PET images of sub-centimeter lesions are not quantitative.
Article in EJNMMI physics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
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41 citing papers in PubMed, 2 syntheses or guidelines pooled it.
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- Effect of Tumor-Pixel Positioning on the Variability of SUV Measurements in PET Images.Asia Oceania journal of nuclear medicine & biology · 2023Article
- The maximum standardized uptake value in patients with recurrent or persistent prostate cancer after radical prostatectomy and PSMA-PET-guided salvage radiotherapy-a multicenter retrospective analysis.European journal of nuclear medicine and molecular imaging · 2022Article
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- Brain partial volume correction with point spreading function reconstruction in high-resolution digital PET: comparison with an MR-based method in FDG imaging.Annals of nuclear medicine · 2022Article
- EARL compliance measurements on the biograph vision Quadra PET/CT system with a long axial field of view.EJNMMI physics · 2022Article
- Impact of point-spread function reconstruction on dynamic and staticQuantitative imaging in medicine and surgery · 2022Article
- New standards for phantom image quality and SUV harmonization range for multicenter oncology PET studies.Annals of nuclear medicine · 2022Article
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4 authors.
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Abstract
backgroundPET image reconstruction methods include modeling of resolution degrading phenomena, often referred to as point-spread function (PSF) reconstruction. The aim of this study was to develop a clinically relevant phantom and characterize the reproducibility and accuracy of high-resolution PSF reconstructed images of small lesions, which is a prerequisite for using PET in the prediction and evaluation of responses to treatment. Sets of small homogeneous
resultsFor non-PSF images, RCs were reproducible and fell monotonically as the sphere diameter decreased, which is the expected behavior. PSF images converged slower and had artifacts: RCs did not fall monotonically as sphere diameters decreased but had a maximum RC for sphere sizes around 8 mm, RCs could be greater than 1, and RCs were less reproducible. To some degree, post-reconstruction filters could suppress PSF artifacts.
conclusionsHigh-resolution PSF images of small lesions showed artifacts that could lead to serious misinterpretations when used for monitoring treatment response. Thus, it could be safer to use non-PSF reconstruction for quantitative purposes unless PSF reconstruction parameters are optimized for the specific task.
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