Evidence map›Paper›PMID 28091892›Full record

Observational studyObesity surgery2017

Bariatric Roux-En-Y Gastric Bypass Surgery: Adipocyte Proteins Involved in Increased Bone Remodeling in Humans.

Maria Fernanda G Biagioni, Adriana L Mendes, Célia Regina Nogueira, Celso V Leite, Loraine Gollino, Gláucia Mfs Mazeto

Open access · greenAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Obesity surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Observational
  9. Observational
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  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Maria Fernanda G BiagioniInternal Medicine Department (MFGB, ALM, CRN, LG, GMFSM), Botucatu Medical School, São Paulo State University, FMB-Unesp, Botucatu, Brazil. mafebiagioni@yahoo.com.br.
Adriana L MendesInternal Medicine Department (MFGB, ALM, CRN, LG, GMFSM), Botucatu Medical School, São Paulo State University, FMB-Unesp, Botucatu, Brazil.
Célia Regina NogueiraInternal Medicine Department (MFGB, ALM, CRN, LG, GMFSM), Botucatu Medical School, São Paulo State University, FMB-Unesp, Botucatu, Brazil.
Celso V LeiteSurgery Department (CVL), Botucatu Medical School, São Paulo State University, FMB-Unesp, Botucatu, Brazil.
Loraine GollinoInternal Medicine Department (MFGB, ALM, CRN, LG, GMFSM), Botucatu Medical School, São Paulo State University, FMB-Unesp, Botucatu, Brazil.
Gláucia Mfs MazetoInternal Medicine Department (MFGB, ALM, CRN, LG, GMFSM), Botucatu Medical School, São Paulo State University, FMB-Unesp, Botucatu, Brazil.
Universidade Estadual Paulista (Unesp) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeBariatric surgery has been associated with bone remodeling changes. The action of adipokines on the expression of receptor activator of nuclear factor kappa β ligand (RANKL) and osteoprotegerin (OPG) and on an increase in sclerostin could be related to these changes. MATERIALS AND

methodsThis study aimed to assess the repercussions of weight loss, fat mass (FM), and fat-free mass (FFM) loss and biochemical and hormonal changes on bone remodeling markers after Roux-en-Y gastric bypass (RYGB). Anthropometric data, parathyroid hormone (PTH), bone-specific alkaline phosphatase (BSAP), collagen type 1 C-telopeptide (CTX), 25-hydroxy vitamin D (25-OH-VitD), leptin, adiponectin, RANKL, OPG, and sclerostin of 30 menstruating women were measured preoperatively (Pre), and 3, 12, and 24 months (m) after RYGB.

resultsLeptin (34.4 (14.7; 51.9) vs. 22.5 (1.9; 52.7) ng/mL) and OPG (3.6 (1.1; 11.5) vs. 3.4 (1.5; 6) pmol/L) decreased, and adiponectin (7.4 (1.7; 18.4) vs. 13.8 (3.0; 34.6) μg/mL), CTX (0.2 (0.1; 2.2) vs. 0.6 (0.4; 6.0) ng/mL), RANKL (0.1 (0.0; 0.5) vs. 0.3 (0.0; 2.0) pmol/L), and sclerostin (21.7 (3.2; 75.1) vs. 34.8 (6.4; 80.5) pmol/L) increased after 3 m. BSAP increased after 12 m (10.1 (5.4; 18.9) vs. 13.9 (6.9; 30.2) μg/mL) (p < 0.005). CTX correlated positively with adiponectin at 24 m and inversely with leptin Pre; OPG at 3 m; weight, FM, FFM, and leptin at 24 m. RANKL correlated directly with weight at 3 m. Sclerostin correlated inversely with weight Pre and FM at 3 m. BSAP correlated negatively with 25-OH-VitD at 12 m, and positively with PTH at 24 m.

conclusionsRYGB induced weight loss, and biochemical, hormonal, and body composition changes are associated with higher bone remodeling.

Indexed as

Gastric BypassAdaptor Proteins, Signal TransducingAdipocytesAdipokinesAdultAnthropometryBiomarkersBone Morphogenetic ProteinsBone RemodelingFemaleGenetic MarkersHumansMiddle AgedObesityOsteoprotegerinProspective StudiesAdaptor Proteins, Signal TransducingAdipokinesBiomarkersBone Morphogenetic ProteinsGenetic MarkersOsteoprotegerinRANK LigandSOST protein, humanTNFRSF11B protein, humanBariatric surgeryBiomarkersBone remodelingCytokinesWnt/β-catenin/LRPs

Identifiers

PMID28091892
OpenAlexW2573762737

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.