ArticleDocumenta ophthalmologica. Advances in ophthalmology2017
The morphology of human rod ERGs obtained by silent substitution stimulation.
Article in Documenta ophthalmologica. Advances in ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Fast ERG 15 Hz flicker protocol for assessing functional changes in the rod system.Documenta ophthalmologica. Advances in ophthalmology · 2026Article
- The mesopic negative response (MeNR): a novel approach to assess retinal ganglion cell function within the rod pathway.Documenta ophthalmologica. Advances in ophthalmology · 2025Article
- Electroretinographic responses to periodic stimuli in primates and the relevance for visual perception and for clinical studies.Visual neuroscience · 2024Review
- PySilSub: An open-source Python toolbox for implementing the method of silent substitution in vision and nonvisual photoreception research.Journal of vision · 2023Article
- Loss of cone function without degeneration in a novel Gnat2 knock-out mouse.Experimental eye research · 2018Article
- Rod- versus cone-driven ERGs at different stimulus sizes in normal subjects and retinitis pigmentosa patients.Documenta ophthalmologica. Advances in ophthalmology · 2018Article
- A Temporal White Noise Analysis for Extracting the Impulse Response Function of the Human Electroretinogram.Translational vision science & technology · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo record transient ERGs from the light-adapted human retina using silent substitution stimuli which selectively reflect the activity of rod photoreceptors. We aim to describe the morphology of these waveforms and examine how they are affected by the use of less selective stimuli and by retinal pathology.
methodsRod-isolating stimuli with square-wave temporal profiles (250/250 ms onset/offset) were presented using a 4 primary LED ganzfeld stimulator. Experiment 1: ERGs were recorded using a rod-isolating stimulus (63 ph Td, rod contrast, C
resultsThe rod-isolated ERGs elicited from normal subjects had a waveform with a positive onset component followed by a negative offset. Response amplitude was maximal at retinal illuminances <100 ph Td and was virtually abolished at 400 ph Td. The use of non-selective stimuli altered the ERG waveform eliciting more photopic-like ERG responses. Rod ERGs recorded from rod monochromats had similar features to those recorded from normal trichromats, in contrast to those recorded from participants with CSNB which had an electronegative appearance.
conclusionsOur results demonstrate that ERGs elicited by silent substitution stimuli can selectively reflect the operation of rod photoreceptors in the normal, light-adapted human retina.
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