ArticleClinical oral investigations2017
The influence of dental treatment on the development of osteoradionecrosis after radiotherapy by modern irradiation techniques.
Article in Clinical oral investigations, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Incidence of mandibular osteoradionecrosis (MORN) after intensity modulated radiotherapy (IMRT) versus 3D conformal radiotherapy (3D-CRT): A systematic review.Medicina oral, patologia oral y cirugia bucal · 2022Pooled it
- Incidence and Site-Specific Risk Factors of Jaw Osteoradionecrosis for Head and Neck Patients in the IMRT/VMAT Era: Evidence From a Large, Hospital-Based Cohort.Head & neck · 2026Article
- Analysis of health insurance data on dental treatment and the occurrence of osteoradionecrosis of the jaw.BMC oral health · 2025Article
- In Reference to Amina et al (2022) Titled: 'Radiation Therapy Treatment Outcomes for Patients with Head and Neck Cancer: A Tertiary Care Centre Experience in a Tier Three Town' (doi: 10.1007/s12070-021-02810-7).Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- Factors Influencing the Survival Rate of Teeth and Implants in Patients after Tumor Therapy to the Head and Neck Region-Part 1: Tooth Survival.Journal of clinical medicine · 2022Article
- Periodontal therapy for patients before and after radiotherapy: A review of the literature and topics of interest for clinicians.Medicina oral, patologia oral y cirugia bucal · 2018Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this study was to analyze the influence of dental treatment on the development of osteoradionecrosis (ORN) of the jaw.
methodsThis study included the data of 776 patients who underwent 3D-CRT or IMRT because of head and neck cancer. Sex, dental status before and after radiotherapy (RT), tumor site, bone surgery during tumor operation, concomitant chemotherapy, and the development of an advanced ORN were documented for each patient. The patients' dentitions before and after RT were classified into four groups with regard to the number and localization of the remaining teeth. Differences between the patients with ORN and patients without ORN with regard to the teeth's condition before and after RT, and with regard to the extent of dental treatment were determined descriptively. Cox proportional hazards regression to study the association between dentition and the development of ORN.
resultsThe extent of dental treatment in patients with and without ORN did not differ in a clinically relevant way. The highest risk of developing ORN was observed in patients who had undergone primary bone surgery during the tumor operation (HR = 5.58, 95%CI 2.91-10.7) and patients who had a tumor in the oral cavity (HR = 4.84, 95%CI 1.37-17.11).
conclusionsBased on the results of this study, tumor localization and its required treatment are prognostic factors for the development of ORN. CLINICAL SIGNIFICANCE: After implementing a consequent dental treatment scheme, no influence of dentition on the risk of developing ORN could be demonstrated. Patients with a lower risk could prospectively benefit from a more moderate dental treatment scheme.
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