Evidence map›Paper›PMID 28091799›Full record

ReviewCurrent psychiatry reports2017

Prenatal Risk Factors and the Etiology of ADHD-Review of Existing Evidence.

Emma Sciberras, Melissa Mulraney, Desiree Silva, David Coghill

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current psychiatry reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

116 citing papers in PubMed, 11 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Parental Age and the Risk of ADHD in Offspring: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021
    Pooled it
  10. The Association between Lead and Attention-Deficit/Hyperactivity Disorder: A Systematic Review.International journal of environmental research and public health · 2019
    Pooled it
  11. Pooled it
  12. Trial
  13. Trial
  14. Article
  15. The association between bronchopulmonary dysplasia severity and neurodevelopmental disorders.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Emma SciberrasDeakin University, Melbourne, VIC, Australia.
Melissa MulraneyMurdoch Childrens Research Institute, Parkville, VIC, Australia.
Desiree SilvaSchool of Paediatrics and Child Health, University of Western, Perth, Australia.
David CoghillMurdoch Childrens Research Institute, Parkville, VIC, Australia. david.coghill@unimelb.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While it is well accepted that attention-deficit/hyperactivity disorder (ADHD) is a highly heritable disorder, not all of the risk is genetic. It is estimated that between 10 and 40% of the variance associated with ADHD is likely to be accounted for by environmental factors. There is considerable interest in the role that the prenatal environment might play in the development of ADHD with previous reviews concluding that despite demonstration of associations between prenatal risk factors (e.g. prematurity, maternal smoking during pregnancy) and ADHD, there remains insufficient evidence to support a definite causal relationship. This article provides an update of research investigating the relationship between prenatal risk factors and ADHD published over the past 3 years. Recently, several epidemiological and data linkage studies have made substantial contributions to our understanding of this relationship. In particular, these studies have started to account for some of the genetic and familial confounds that, when taken into account, throw several established findings into doubt. None of the proposed prenatal risk factors can be confirmed as causal for ADHD, and the stronger the study design, the less likely it is to support an association. We need a new benchmark for studies investigating the etiology of ADHD whereby there is an expectation not only that data will be collected prospectively but also that the design allows the broad range of genetic and familial factors to be accounted for.

Indexed as

Gene-Environment InteractionAttention Deficit Disorder with HyperactivityCausalityChildChild, PreschoolCross-Sectional StudiesFemaleGenetic Association StudiesHumansInfantInfant, Low Birth WeightInfant, NewbornInfant, Premature, DiseasesMalePregnancyPrenatal Exposure Delayed EffectsADHDEnvironmentalEtiologyPregnancyPrenatal

Identifiers

PMID28091799

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.