ArticleDer Anaesthesist2017
[Deaths from propofol abuse : Survey of institutes of forensic medicine in Germany, Austria and Switzerland].
Article in Der Anaesthesist, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Microglial Activation Is Associated with Hippocampal Synaptic Degeneration and Cognitive Deficits Following Repeated Propofol Exposure.International journal of molecular sciences · 2026Article
- Review
- A comprehensive analysis of propofol abuse, addiction and neuropharmacological aspects: an updated review.Korean journal of anesthesiology · 2025Review
- Non-Opioid Anesthetics Addiction: A Review of Current Situation and Mechanism.Brain sciences · 2023Review
- Factors associated with euphoria in a large subset of cases using propofol sedation during gastrointestinal endoscopy.Frontiers in psychiatry · 2023Article
- Dependence liability of lormetazepam: are all benzodiazepines equal? The case of the new i.v. lormetazepam for anesthetic procedures.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- Interpol review of controlled substances 2016-2019.Forensic science international. Synergy · 2020Review
- [Addictive disorders in physicians].Der Nervenarzt · 2020Article
- Propofol sedation during gastrointestinal endoscopy arouses euphoria in a large subset of patients.United European gastroenterology journal · 2018Article
- A homemade furnace. Influence of occupational skills in a fire-related planned complex suicide.Forensic science, medicine, and pathology · 2018Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous references suggesting a high mortality of propofol addiction in medical personnel were mostly based on surveys of the heads of medical departments or case reports; therefore, a questionnaire was sent to 48 forensic medicine departments in Germany, Austria and Switzerland concerning the number of autopsies carried out between 2002-2112 on medical personnel with the suspicion of abuse of propofol or other analgesics. The response rate was 67%. In 16 out of the 32 responding departments 39 deaths (27 males) were observed with previous connections to anesthesiology, intensive care or emergency departments of which 22 were physicians, 13 nurses, 2 other personnel and 2 were unknown. Propofol was the major cause of death in 33 cases (85%), in 8 cases including 7 with propofol, an unintentional accident was recorded and 29 were determined to be suicide. In 14 cases chronic abuse was denied but actually excluded by toxicological analysis in only 2 cases. In 11 cases involving suicide the question of abuse was not investigated. This survey confirmed previous data about the central role of propofol for the fatal outcome of addiction and suicide of anesthetists and other medical personnel. A dual prevention strategy with low-threshold offers for persons at risk and strategies for early detection is urgently needed including a stricter control of dispensing, improvement in forensic medical documentation and the use of toxicological investigations in every case of suspected abuse.
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