ArticleScientific reports2017
Paracrine cross-talk between skeletal muscle and macrophages in exercise by PGC-1α-controlled BNP.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Exercise-induced osteoimmune crosstalk: a virtuous cycle between bone remodeling and immune regulation.Frontiers in endocrinology · 2026Review
- Kynurenine Pathway Metabolites as Mediators of Exercise-Induced Mood Enhancement, Fatigue Resistance, and Neuroprotection.International journal of molecular sciences · 2025Review
- Impact of exercise on immune cell infiltration in muscle tissue: implications for muscle repair and chronic disease.Clinical and experimental medicine · 2025Review
- Conductive Microgel Annealed Scaffolds Enhance Myogenic Potential of Myoblastic Cells.Advanced healthcare materials · 2024Article
- Control of muscle satellite cell function by specific exercise-induced cytokines and their applications in muscle maintenance.Journal of cachexia, sarcopenia and muscle · 2024Review
- Potential mechanisms of exercise for relieving inflammatory pain: a literature review of animal studies.Frontiers in aging neuroscience · 2024Review
- Intravital microscopy of satellite cell dynamics and their interaction with myeloid cells during skeletal muscle regeneration.Science advances · 2023Article
- Harmonizing Magnetic Mitohormetic Regenerative Strategies: Developmental Implications of a Calcium-Mitochondrial Axis Invoked by Magnetic Field Exposure.Bioengineering (Basel, Switzerland) · 2023Review
- The molecular athlete: exercise physiology from mechanisms to medals.Physiological reviews · 2023Review
- PGC-1α in the myofibers regulates the balance between myogenic and adipogenic progenitors affecting muscle regeneration.iScience · 2022Article
- Article
- Effect of immune modulation on the skeletal muscle mitochondrial exercise response: An exploratory study in mice with cancer.PloS one · 2021Article
- The Role of the Skeletal Muscle Secretome in Mediating Endurance and Resistance Training Adaptations.Frontiers in physiology · 2021Review
- Exercise-Released Myokines in the Control of Energy Metabolism.Frontiers in physiology · 2020Review
- The Role of NADPH Oxidases in the Etiology of Obesity and Metabolic Syndrome: Contribution of Individual Isoforms and Cell Biology.Antioxidants & redox signaling · 2019Review
- Microphysiological sensing platform for an in-situ detection of tissue-secreted cytokines.Biosensors & bioelectronics: X · 2019Article
- Microvascular Adaptations to Exercise: Protective Effect of PGC-1 Alpha.American journal of hypertension · 2018Article
- Endocrine Crosstalk Between Skeletal Muscle and the Brain.Frontiers in neurology · 2018Review
- Natriuretic Peptides: The Case of Prostate Cancer.Molecules (Basel, Switzerland) · 2017Review
- Exercise-dependent regulation of the tumour microenvironment.Nature reviews. Cancer · 2017Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Activation of resident and infiltrating immune cells is a central event in training adaptation and other contexts of skeletal muscle repair and regeneration. A precise orchestration of inflammatory events in muscle fibers and immune cells is required after recurrent contraction-relaxation cycles. However, the mechanistic aspects of this important regulation remain largely unknown. We now demonstrate that besides a dominant role in controlling cellular metabolism, the peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) also has a profound effect on cytokine expression in muscle tissue. Muscle PGC-1α expression results in activation of tissue-resident macrophages, at least in part mediated by PGC-1α-dependent B-type natriuretic peptide (BNP) production and secretion. Positive effects of exercise in metabolic diseases and other pathologies associated with chronic inflammation could accordingly involve the PGC-1α-BNP axis and thereby provide novel targets for therapeutic approaches.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.