ArticleScientific reports2017
Non-invasive optical estimate of tissue composition to differentiate malignant from benign breast lesions: A pilot study.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04767659 (Optical Monitoring of Neoadjuvant Chemotherapy and Prediction of Pathological Complete Response in Breast Cancer Patients), which is not on this map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Optical Monitoring of Neoadjuvant Chemotherapy and Prediction of Pathological Complete Response in Breast Cancer Patients
Who cites it
30 citing papers in PubMed, 88 citations in OpenAlex.
- Water, Collagen, and Lipid Content in the Human Skin and Muscles Assessed with Near-Infrared Diffuse Reflectance Spectroscopy and Multi-Spectral Optoacoustic Tomography.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Widefield ultra-high-density optical breast tomography system supplementing x-ray mammography.Scientific reports · 2025Article
- In vivo optimization of the experimental conditions for the non-invasive optical assessment of breast density.Scientific reports · 2024Article
- Monitoring of neoadjuvant chemotherapy through time domain diffuse optics: breast tissue composition changes and collagen discriminative potential.Biomedical optics express · 2024Article
- Improving diffuse optical tomography imaging quality using APU-Net: an attention-based physical U-Net model.Journal of biomedical optics · 2024Article
- Experience using 675 nm laser on three cases of Fitzpatrick skin type IV-V with melasma.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Article
- Review
- Breast Cancer Diagnosis Using Extended-Wavelength-Diffuse Reflectance Spectroscopy (EW-DRS)-Proof of Concept in Ex Vivo Breast Specimens Using Machine Learning.Diagnostics (Basel, Switzerland) · 2023Article
- The 675-nm wavelength for treating facial melasma.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2023Article
- Design of a Low-Cost Diffuse Optical Mammography System for Biomedical Image Processing in Breast Cancer Diagnosis.Sensors (Basel, Switzerland) · 2023Article
- How much do time-domain functional near-infrared spectroscopy (fNIRS) moments improve estimation of brain activity over traditional fNIRS?Neurophotonics · 2023Article
- Investigating the feasibility of a hand-held photoacoustic imaging probe for margin assessment during breast conserving surgery.Photoacoustics · 2022Article
- Anthropomorphic Polydimethylsiloxane silicone-based phantom for Diffuse Optical Imaging.Heliyon · 2022Article
- 2.5 Hz sample rate time-domain near-infrared optical tomography based on SPAD-camera image tissue hemodynamics.Biomedical optics express · 2022Article
- Narrowband diffuse reflectance spectroscopy in the 900-1000 nm wavelength region to quantify water and lipid content of turbid media.Biomedical optics express · 2021Article
- Broadband diffuse optical spectroscopy of absolute methemoglobin concentration can distinguish benign and malignant breast lesions.Journal of biomedical optics · 2021Article
- Optical tissue measurements of invasive carcinoma and ductal carcinoma in situ for surgical guidance.Breast cancer research : BCR · 2021Article
- A novel method for objectively, rapidly and accurately evaluating burn depth via near infrared spectroscopy.Burns & trauma · 2021Article
- Resolving tissue chromophore concentration at MRI resolution using multi-wavelength photo-magnetic imaging.Biomedical optics express · 2020Article
- Lipid-weighted intraoperative photoacoustic tomography of breast tumors: Volumetric comparison to preoperative MRI.Photoacoustics · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several techniques are being investigated as a complement to screening mammography, to reduce its false-positive rate, but results are still insufficient to draw conclusions. This initial study explores time domain diffuse optical imaging as an adjunct method to classify non-invasively malignant vs benign breast lesions. We estimated differences in tissue composition (oxy- and deoxyhemoglobin, lipid, water, collagen) and absorption properties between lesion and average healthy tissue in the same breast applying a perturbative approach to optical images collected at 7 red-near infrared wavelengths (635-1060 nm) from subjects bearing breast lesions. The Discrete AdaBoost procedure, a machine-learning algorithm, was then exploited to classify lesions based on optically derived information (either tissue composition or absorption) and risk factors obtained from patient's anamnesis (age, body mass index, familiarity, parity, use of oral contraceptives, and use of Tamoxifen). Collagen content, in particular, turned out to be the most important parameter for discrimination. Based on the initial results of this study the proposed method deserves further investigation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.